Choleretic effect of Curcuma comosa rhizome extracts in rats

Choleretic properties of various extracts of Curcuma comosa Roxb. (Zingiberacea) were investigated in rats. Butanol and ethyl acetate extracts of the rhizome were the most effective in producing a choleretic effect. Intraduodenal administration of the ethyl acetate extract caused a dose-dependent stimulation of bile secretion. A high dose of the extract increased bile flow rate with decreased bile salt concentration whereas low doses increased the bile flow rate without altering bile salt concentration. With regard to the total output of biliary constituents, the high dose of extract did not alter secretory bile salt output, but markedly increased biliary cholesterol output. Concurrent with increased biliary cholesterol secretion. C. comosa caused a decrease in plasma cholesterol level. This result suggests potential development of this plant as a source of choleretic and hypocholesterolemic drugs.