Epidemiology and natural history of hepatocellular carcinoma

被引:271
作者
McGlynn, KA
London, WT
机构
[1] NCI, HREB DCEG, Rockville, MD 20892 USA
[2] Fox Chase Canc Ctr, Div Populat Sci, Philadelphia, PA 19111 USA
关键词
hepatocellular carcinoma; incidence; hepatitis B virus; hepatitis C virus; aflatoxin B-I;
D O I
10.1016/j.bpg.2004.10.004
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatocellular carcinoma (HCC) is a major contributor to cancer incidence and mortality. There is a wide variation, however, in the global distribution of HCC. Eighty percent of the burden is borne by countries in Asia and sub-Saharan Africa. In most high-risk countries, principal risk factors include infection with hepatitis B virus and dietary exposure to aflatoxin B-1. In contrast, hepatitis C virus and alcohol consumption are more important risk factors in low-risk countries. In recent years, the incidence of HCC has decreased in some high-risk countries and increased in some low-risk countries. Reasons for both trends are not completely understood, but are likely related to public health efforts in Asia and the increase in hepatitis C virus infection in low-risk countries. Vaccination programs against hepatitis B virus will likely decrease the HCC rate even further in decades to come.
引用
收藏
页码:3 / 23
页数:21
相关论文
共 134 条
[11]   PREVALENCE OF CHRONIC LIVER-DISEASE IN THE GENERAL-POPULATION OF NORTHERN ITALY - THE DIONYSOS STUDY [J].
BELLENTANI, S ;
TIRIBELLI, C ;
SACCOCCIO, G ;
SODDE, M ;
FRATTI, N ;
DEMARTIN, C ;
CRISTIANINI, G ;
ARMOCIDA, C ;
BARBANI, A ;
BARONI, D ;
BRANDI, G ;
CROCE, LS ;
FERRETTI, I ;
FIGLIOLI, GF ;
MANENTI, AL ;
MANENTI, F ;
MARCHEGIANO, P ;
MESSORI, B ;
PASSAMONTI, S ;
POPPI, C ;
SASSATELLI, R .
HEPATOLOGY, 1994, 20 (06) :1442-1449
[12]  
Beutler Ernest, 1996, Blood Cells Molecules and Diseases, V22, P187, DOI 10.1006/bcmd.1996.0027
[13]  
BILLINGSLEY GD, 1993, AM J HUM GENET, V52, P343
[14]   Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis [J].
Bonkovsky, HL ;
Jawaid, Q ;
Tortorelli, K ;
LeClair, P ;
Cobb, J ;
Lambrecht, RW ;
Banner, BF .
JOURNAL OF HEPATOLOGY, 1999, 31 (03) :421-429
[15]   SELECTIVE G-MUTATION TO T-MUTATION OF P53 GENE IN HEPATOCELLULAR-CARCINOMA FROM SOUTHERN AFRICA [J].
BRESSAC, B ;
KEW, M ;
WANDS, J ;
OZTURK, M .
NATURE, 1991, 350 (6317) :429-431
[16]   Grading and staging the histopathological lesions of chronic hepatitis. The Knodell histology activity index and beyond [J].
Brunt, EM .
HEPATOLOGY, 2000, 31 (01) :241-246
[17]   Nonalcoholic steatohepatitis: A proposal for grading and staging the histological lesions [J].
Brunt, EM ;
Janney, CG ;
Di Bisceglie, AM ;
Neuschwander-Tetri, BA ;
Bacon, BR .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 1999, 94 (09) :2467-2474
[18]   Expanding the natural history from cryptogenic cirrhosis to of nonalcoholic steatohepatitis: Hepatocellular carcinoma [J].
Bugianesi, E ;
Leone, N ;
Vanni, E ;
Marchesini, G ;
Brunello, F ;
Carucci, P ;
Musso, A ;
De Paolis, P ;
Capussotti, L ;
Salizzoni, M ;
Rizzetto, M .
GASTROENTEROLOGY, 2002, 123 (01) :134-140
[19]  
Byron D, 1996, HEPATOLOGY, V24, P813
[20]   Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults [J].
Calle, EE ;
Rodriguez, C ;
Walker-Thurmond, K ;
Thun, MJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (17) :1625-1638