Diving seals, ischemia-reperfusion and oxygen radicals

被引：59

作者：

Elsner, R ^{[1
]}

Oyasæter, S

Almaas, R

Saugstad, OD

机构：

[1] Univ Alaska, Inst Marine Sci, Fairbanks, AK 99775 USA

[2] Univ Oslo, Natl Hosp, Dept Pediat Res, N-0027 Oslo, Norway

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY | 1998年 / 119卷 / 04期

关键词：

seals; diving; oxygen radicals; hypoxanthine; superoxide dismutase;

D O I：

10.1016/S1095-6433(98)00012-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cardiovascular adaptations of seals that contribute to their ability to tolerate long periods of diving asphyxial hypoxia result in episodic regional ischemia during diving and abrupt reperfusion upon termination of the dive. These conditions might be expected to result in production of oxygen-derived free radicals and other forms of highly reactive oxygen species. Seal organs vary during dives with respect to the degree and persistence of ischemia. Myocardial perfusion is reduced and intermittent; kidney circulation is vigorously vasoconstricted. Heart and kidney tissues from ringed seals (Phoca hispida) and domestic pigs (Sus scrofa) were compared in reactions to experimental ischemia. Resulting production of hypoxanthine, indicative of ATP degradation, was higher in pig than in seal tissues. Activity of superoxide dismutase (SOD), an oxygen radical scavenger, was higher in seal heart. We suggest that these results indicate enhanced protective cellular mechanisms in seals against the potential hazard of highly reactive oxygen forms. SOD activity was unexpectedly higher in pig kidney. (C) 1998 Elsevier Science Inc. All rights reserved.

引用

页码：975 / 980

页数：6

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