Age-related changes in total and high-density-lipoprotein cholesterol in elderly Dutch men

Objectives. This study investigated changes in total and high-density-lipoprotein cholesterol (HDL) concentrations with age and time in elderly men. Methods. A cohort of men born between 1900 and 1920 from the Dutch town of Zutphen was examined in 1977 and 1978 (n = 571), 1985 (n = 885), 1990 (n = 555) and 1993 (n = 345). Linear regression analysis and random-effects models were used to assess cross-sectional and longitudinal age- and time-related changes in cholesterol concentrations. Results. In both cross-sectional and longitudinal analyses, total cholesterol decreased by 0.04 mmol/L a year with age. The longitudinal change was observed in the entire population as well as in men who participated in all four examinations (n = 135) and in a subgroup of men who were free of common chronic diseases, were not on cholesterol-lowering medication or a prescribed diet, and rated themselves as being ''healthy'' (n = 64). HDL cholesterol did not change significantly with age neither on a cross-sectional nor on a longitudinal basis. Conclusions. Among elderly men, total cholesterol diminishes with age both on a cross-sectional and on a longitudinal basis; HDL cholesterol does not vary with age in anyway.