Effectiveness of Lanzhou lamb rotavirus vaccine against rotavirus gastroenteritis requiring hospitalization: A matched case-control study

被引：76

作者：

Fu, Chuanxi ^{[1
]}

Wang, Ming ^{[1
]}

Liang, Jianhua ^{[1
]}

He, Tongjie ^{[2
]}

Wang, Dahu ^{[1
]}

Xu, Jianxiong ^{[1
]}

机构：

[1] Guangzhou Ctr Dis Control & Prevent, Guangzhou, Peoples R China

[2] Guangzhou Childrens Hosp, Guangzhou, Peoples R China

来源：

VACCINE | 2007年 / 25卷 / 52期

关键词：

rotavirus; vaccine effectiveness; acute gastroenteritis;

D O I：

10.1016/j.vaccine.2007.10.036

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We sought to determine the vaccine effectiveness (VE) of Lanzhou lamb rotavirus (LLR) vaccine against rotavirus gastroenteritis in children <5 requiring hospitalization. Children hospitalized 2002-2004 with rotavirus gastroenteritis were matched by gender, age and community to 838 controls. VE was calculated for one or more doses of LLR vaccine with 95% confidence intervals (Q. For one dose versus zero doses, LLR vaccine VE was 73.3% (95% CI, range 61.2-81.6%). VE of one dose versus zero doses was higher in children 12-23 months than in children 2-11 months (80.9% versus 60.0%). We found one dose moderately effective in preventing rotavirus gastroenteritis requiring hospitalization. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：8756 / 8761

页数：6

共 23 条

[1]

ADCOCK P, 2000, WHOVB0023

[2]

[Anonymous], CHIN J BIOL

[3]

BAI ZS, 2004, VACCINOLOGY, V3, P1357

[4] First report from the Asian rotavirus surveillance network [J].

Bresee, J ;

Fang, ZY ;

Wang, B ;

Nelson, EAS ;

Tam, J ;

Soenarto, Y ;

Wilopo, SA ;

Kilgore, P ;

Kim, JS ;

Kang, JO ;

Lan, WS ;

Gaik, CL ;

Moe, K ;

Chen, KT ;

Jiraphongsa, C ;

Pongsuwanna, Y ;

Van Man, N ;

Van Tu, P ;

Luan, LT ;

Hummelman, E ;

Gentsch, JR ;

Glass, R .

EMERGING INFECTIOUS DISEASES, 2004, 10 (06) :988-995

[5]

BRESEE J, 2002, WHOVB0215

[6] Evaluating new vaccines for developing countries - Efficacy or effectiveness? [J].

Clemens, J ;

Brenner, R ;

Rao, M ;

Tafari, N ;

Lowe, C .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 275 (05) :390-397

[7]

Cunliffe NA, 1998, B WORLD HEALTH ORGAN, V76, P525

[8] Sentinel hospital surveillance for rotavirus diarrhea in the People's Republic of China, August 2001 July 2003 [J].

Fang, ZY ;

Wang, B ;

Kilgore, PE ;

Bresee, JS ;

Zhang, LJ ;

Sun, LW ;

Du, ZQ ;

Tang, JY ;

Hou, AC ;

Shen, H ;

Song, XB ;

Nyambat, B ;

Hummelman, E ;

Xu, ZY ;

Glass, RI .

JOURNAL OF INFECTIOUS DISEASES, 2005, 192 :S94-S99

[9] Rotavirus vaccines and the prevention of hospital-acquired diarrhea in children [J].

Fischer, TK ;

Bresee, JS ;

Glass, RI .

VACCINE, 2004, 22 :S49-S54

[10] Rotavirus vaccines: current prospects and future challenges [J].

Glass, Roger I. ;

Parashar, Umesh D. ;

Bresee, Joseph S. ;

Turcios, Reina ;

Fischer, Theo K. ;

Widdowson, Marc-Alain ;

Jiang, Baoming ;

Gentsch, Jon R. .

LANCET, 2006, 368 (9532) :323-332

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