Mass spectrometric studies on the fragmentation and structural characterization of aminoacyl derivatives of kanamycin A

被引：18

作者：

Kotretsou, SI ^{[1
]}

Constantinou-Kokotou, V ^{[1
]}

机构：

[1] Agr Univ Athens, Chem Lab, Athens 11855, Greece

来源：

CARBOHYDRATE RESEARCH | 1998年 / 310卷 / 1-2期

关键词：

kanamycin; aminoglycoside antibiotics; FAB mass spectrometry; ESI mass spectrometry; tandem mass spectrometry;

D O I：

10.1016/S0008-6215(98)00169-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Described herein are the fragmentation pathways of kanamycin A and its 6'-N- and 1-N-acyl derivatives, as well as the determination of their positional isomers by FARMS and ESIMS in combination with tandem mass spectrometry. The presence or absence of key ions and the difference in abundance of common ions are correlated with the position of the substitution. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：121 / 127

页数：7

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