PAF and PAF acetylhydrolase in the nervous system

被引：16

作者：

Hattori, M

Aoki, J

Arai, H

Inoue, K

机构：

来源：

JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING | 1996年 / 14卷 / 1-3期

关键词：

PAF acetylhydrolase; isoforms; Miller-Dicker lissencephaly; Zellweger syndrome;

D O I：

10.1016/0929-7855(96)00514-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PAF acetylhydrolase is a key enzyme of PAF inactivation. Intracellular PAF acetylhydrolase isoform Ib is a heterotrimeric enzyme composed of alpha-, beta- and gamma-subunits. The beta- and gamma-subunits act as a catalytic unit and their amino acid sequences are homologous. The alpha-subunit is not essential for catalytic activity but is a product of the causative gene for Miller-Dicker lissencephaly, suggesting this subunit plays an important role in brain development.

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页码：99 / 102

页数：4

相关论文

共 9 条

[1] CDNA CLONING OF HUMAN CYTOSOLIC PLATELET-ACTIVATING-FACTOR ACETYLHYDROLASE GAMMA-SUBUNIT AND ITS MESSENGER-RNA EXPRESSION IN HUMAN TISSUES [J].

ADACHI, H ;

TSUJIMOTO, M ;

HATTORI, M ;

ARAI, H ;

INOUE, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 214 (01) :180-187

[2] PURIFICATION AND CHARACTERIZATION OF PLATELET-ACTIVATING-FACTOR ACETYLHYDROLASE-II FROM BOVINE LIVER CYTOSOL [J].

HATTORI, K ;

HATTORI, M ;

ADACHI, H ;

TSUJIMOTO, M ;

ARAI, H ;

INOUE, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (38) :22308-22313

[3] Cloning and expression of a cDNA encoding the beta-subunit (30-kDa subunit) of bovine brain platelet-activating factor acetylhydrolase [J].

Hattori, M ;

Adachi, H ;

Aoki, J ;

Tsujimoto, M ;

Arai, H ;

Inoue, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (52) :31345-31352

[4]

HATTORI M, 1993, J BIOL CHEM, V268, P18748

[5]

HATTORI M, 1994, J BIOL CHEM, V269, P23150

[6] MILLER-DIEKER LISSENCEPHALY GENE ENCODES A SUBUNIT OF BRAIN PLATELET-ACTIVATING-FACTOR [J].

HATTORI, M ;

ADACHI, H ;

TSUJIMOTO, M ;

ARAI, H ;

INOUE, K .

NATURE, 1994, 370 (6486) :216-218

[7]

REINER O, 1995, J NEUROSCI, V15, P3730

[8] ANTIINFLAMMATORY PROPERTIES OF A PLATELET-ACTIVATING-FACTOR ACETYLHYDROLASE [J].

TJOELKER, LW ;

WILDER, C ;

EBERHARDT, C ;

STAFFORINI, DM ;

DIETSCH, G ;

SCHIMPF, B ;

HOOPER, S ;

LETRONG, H ;

COUSENS, LS ;

ZIMMERMAN, GA ;

YAMADA, Y ;

MCINTYRE, TM ;

PRESCOTT, SM ;

GRAY, PW .

NATURE, 1995, 374 (6522) :549-553

[9] BINDING OF PLECKSTRIN HOMOLOGY DOMAINS TO WD40/BETA-TRANSDUCIN REPEAT CONTAINING SEGMENTS OF THE PROTEIN PRODUCT OF THE LIS-1 GENE [J].

WANG, DS ;

SHAW, R ;

HATTORI, M ;

ARAI, H ;

INOUE, K ;

SHAW, G .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 209 (02) :622-629