A Biomimetic Core-Shell Platform for Miniaturized 3D Cell and Tissue Engineering

被引：69

作者：

Agarwal, Pranay ^{[1
,2
]}

Choi, Jung Kyu ^{[1
,2
]}

Huang, Haishui ^{[1
,2
,3
]}

Zhao, Shuting ^{[1
,2
]}

Dumbleton, Jenna ^{[1
,2
]}

Li, Jianrong ^{[4
]}

He, Xiaoming ^{[1
,2
,5
]}

机构：

[1] Ohio State Univ, Dept Biomed Engn, Columbus, OH 43210 USA

[2] Ohio State Univ, Dorothy M Davis Heart & Lung Res Inst, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Mech & Aerosp Engn, Columbus, OH 43210 USA

[4] Ohio State Univ, Dept Vet Biosci, Columbus, OH 43210 USA

[5] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION | 2015年 / 32卷 / 08期

基金：

美国国家科学基金会;

关键词：

biomimetic; core-shell microcapsule; 3D culture; follicle; stem cell; FOLLICLE DEVELOPMENT; COLLAGEN SCAFFOLDS; SELF-RENEWAL; CULTURE; MICROCAPSULES; ADHESION; ACID;

D O I：

10.1002/ppsc.201500025

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

This article describes a biomimetic core-shell platform with a collagen-based core and an alginate hydrogel shell for cell and tissue culture. With this system, chemical and physical properties of extracellular matrix (ECM) in the core microenvironment can be controlled to regulate proliferation and development of cells/tissues under miniaturized 3D culture. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：809 / 816

页数：8

共 38 条

[1]

One-step microfluidic generation of pre-hatching embryo-like core-shell microcapsules for miniaturized 3D culture of pluripotent stem cells [J].