A potent dipeptide inhibitor of dipeptidyl peptidase IV

被引：14

作者：

Yamada, M ^{[1
]}

Okagaki, C ^{[1
]}

Higashijima, T ^{[1
]}

Tanaka, S ^{[1
]}

Ohnuki, T ^{[1
]}

Sugita, T ^{[1
]}

机构：

[1] Tanabe Seiyaku Co Ltd, Lead Generat Res Lab, Yodogawa Ku, Osaka 5328505, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 12期

关键词：

antiinflammatories; enzyme inhibitor; immunological activity; peptides and polypeptides;

D O I：

10.1016/S0960-894X(98)00259-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel potent inhibitors of dipeptidyl peptidase IV (DPP-IV) has been developed. A brief structure-activity relationship of the inhibitors was investigated. The dipeptide TSL-225, tryptophyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, was identified with the critical structure for the inhibitory activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1537 / 1540

页数：4

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