Synthesis of 1-O-[(3S,4R)-3-hydroxytetrahydrofuran-4-yl]-α-D-gluco-pyranoside 3,4,3′-trisphosphate as a novel potent IP3 receptor ligand

被引：26

作者：

Tatani, K ^{[1
]}

Shuto, S ^{[1
]}

Ueno, Y ^{[1
]}

Matsuda, A ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 28期

关键词：

glycosidation; inositols; receptors; structure-activity;

D O I：

10.1016/S0040-4039(98)00954-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-O-[(3S,4R)-3-Hydroxytetrahydrofuran-4-yl]-alpha-D-glucopyranoside 3,4,3'-trisphosphate (5) was designed and synthesized as a novel IP3 receptor ligand. This compound bound strongly to IP3 receptor from porcine cerebella with an affinity comparable to that of IP3. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5065 / 5068

页数：4

共 13 条

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