Supramolecular nanostructures designed for high cargo loading capacity and kinetic stability

被引：99

作者：

Yang, Chuan ^{[2
]}

Tan, Jeremy P. K. ^{[2
]}

Cheng, Wei ^{[2
]}

Attia, Amalina Bte Ebrahim ^{[2
]}

Ting, Chloe Tan Yi ^{[2
]}

Nelson, Alshakim ^{[1
]}

Hedrick, James L. ^{[1
]}

Yang, Yi-Yan ^{[2
]}

机构：

[1] IBM Almaden Res Ctr, San Jose, CA 95120 USA

[2] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore

来源：

NANO TODAY | 2010年 / 5卷 / 06期

关键词：

Functional polycarbonate; Block copolymer; Self-assembly; Nanostructures; Mixed micelles; Drug delivery; RING-OPENING POLYMERIZATION; BLOCK-COPOLYMER MICELLES; EPSILON-CAPROLACTONE; NANOPARTICLES; CARBONATE; POLY(ESTER-CARBONATES); BIODISTRIBUTION; POLYCARBONATE; CLEARANCE;

D O I：

10.1016/j.nantod.2010.10.006

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Biodegradable triblock copolymers of PEG, poly(ethyl carbonate) and acidfunctional polycarbonate with precisely controlled molecular weight and well-defined structure were synthesized via organocatalytic living ring opening polymerization, and self-assembled into nanostructures with narrow size distribution. These nanostructures demonstrated exceptionally high loading capacity of an amine-containing cargo (i.e. doxorubicin, an anticancer drug) due to acid base ionic interaction between the cargo and the polymer. To further fine-tune critical properties of drug-loaded micelles, a urea-containing polycarbonate was combined with an acid-functional polycarbonate to form mixed micelles stabilized by hydrogen bonding interactions. The mixed micelles provided greater kinetic stability, nanosize with narrow size distribution and high cargo loading capacity. These nanostructures can be used as carriers to deliver a variety of anticancer drugs that contain amine functional groups. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：515 / 523

页数：9

共 44 条

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Novel functional polycarbonate by lipase-catalyzed ring-opening polymerization of 5-methyl-5-benzyloxycarbonyl-1,3-dioxan-2-one [J].