Targeted nanoparticles for cancer therapy

被引：462

作者：

Gu, Frank X.

Karnik, Rohit

Wang, Andrew Z.

Alexis, Frank

Levy-Nissenbaum, Etgar

Hong, Seungpyo

Langer, Robert S.

Farokhzad, Omid C.

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] Harvard MIT Ctr Canc Nanotechnol, Cambridge, MA 02139 USA

[3] MIT, Dept Mech Engn, Cambridge, MA 02139 USA

[4] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Radiat Oncol, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA

来源：

NANO TODAY | 2007年 / 2卷 / 03期

关键词：

D O I：

10.1016/S1748-0132(07)70083-X

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Over the past decade, there has been an increasing interest in using nanotechnology for cancer therapy. The development of smart targeted nanoparticles (NPs) that can deliver drugs at a sustained rate directly to cancer cells may provide better efficacy and lower toxicity for treating primary and advanced metastatic tumors. We highlight some of the promising classes of targeting molecules that are under development for the delivery of NPs. We also review the emerging technologies for the fabrication of targeted NPs using microfluidic devices.

引用

页码：14 / 21

页数：8

共 139 条

[1] Monoclonal antibody therapy of cancer [J].

Adams, GP ;

Weiner, LM .

NATURE BIOTECHNOLOGY, 2005, 23 (09) :1147-1157

[2] A polymer library approach to suicide gene therapy for cancer [J].

Anderson, DG ;

Peng, WD ;

Akinc, A ;

Hossain, N ;

Kohn, A ;

Padera, R ;

Langer, R ;

Sawicki, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (45) :16028-16033

[3] Biodegradation and biocompatibility of PLA and PLGA microspheres [J].

Anderson, JM ;

Shive, MS .

ADVANCED DRUG DELIVERY REVIEWS, 1997, 28 (01) :5-24

[4] Advanced strategies in liposomal cancer therapy: Problems and prospects of active and tumor specific drug release [J].

Andresen, TL ;

Jensen, SS ;

Jorgensen, K .

PROGRESS IN LIPID RESEARCH, 2005, 44 (01) :68-97

[5]

[Anonymous], CANC FACTS FIG 2007

[6]

ANTONY AC, 1992, BLOOD, V79, P2807

[7] Steps toward mapping the human vasculature by phage display [J].

Arap, W ;

Kolonin, MG ;

Trepel, M ;

Lahdenranta, J ;

Cardó-Vila, M ;

Giordano, RJ ;

Mintz, PJ ;

Ardelt, PU ;

Yao, VJ ;

Vidal, CI ;

Chen, L ;

Flamm, A ;

Valtanen, H ;

Weavind, LM ;

Hicks, ME ;

Pollock, RE ;

Botz, GH ;

Bucana, CD ;

Koivunen, E ;

Cahill, D ;

Troncoso, P ;

Baggerly, KA ;

Pentz, RD ;

Do, KA ;

Logothetis, CJ ;

Pasqualini, R .

NATURE MEDICINE, 2002, 8 (02) :121-127

[8] Preparation and characterization of carbonyl iron/poly(butylcyanoacrylate) core/shell nanoparticles [J].

Arias, J. L. ;

Gallardo, V. ;

Linares-Molinero, F. ;

Delgado, A. V. .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2006, 299 (02) :599-607

[9] Synthesis and characterization of PLGA nanoparticles [J].

Astete, Carlos E. ;

Sabliov, Cristina M. .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2006, 17 (03) :247-289

[10] PLGA-mPEG nanoparticles of cisplatin: in vitro nanoparticle degradation, in vitro drug release and in Vivo drug residence in blood properties [J].

Avgoustakis, K ;

Beletsi, A ;

Panagi, Z ;

Klepetsanis, P ;

Karydas, AG ;

Ithakissios, DS .

JOURNAL OF CONTROLLED RELEASE, 2002, 79 (1-3) :123-135

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