Targeted nanoparticles for cancer therapy

被引:462
作者
Gu, Frank X.
Karnik, Rohit
Wang, Andrew Z.
Alexis, Frank
Levy-Nissenbaum, Etgar
Hong, Seungpyo
Langer, Robert S.
Farokhzad, Omid C.
机构
[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[2] Harvard MIT Ctr Canc Nanotechnol, Cambridge, MA 02139 USA
[3] MIT, Dept Mech Engn, Cambridge, MA 02139 USA
[4] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Radiat Oncol, Boston, MA 02115 USA
[5] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA
关键词
D O I
10.1016/S1748-0132(07)70083-X
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Over the past decade, there has been an increasing interest in using nanotechnology for cancer therapy. The development of smart targeted nanoparticles (NPs) that can deliver drugs at a sustained rate directly to cancer cells may provide better efficacy and lower toxicity for treating primary and advanced metastatic tumors. We highlight some of the promising classes of targeting molecules that are under development for the delivery of NPs. We also review the emerging technologies for the fabrication of targeted NPs using microfluidic devices.
引用
收藏
页码:14 / 21
页数:8
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