The influence of collective behavior on the magnetic and heating properties of iron oxide nanoparticles

被引：86

作者：

Dennis, C. L. ^{[1
]}

Jackson, A. J. ^{[2
,3
]}

Borchers, J. A. ^{[2
]}

Ivkov, R. ^{[4
]}

Foreman, A. R. ^{[4
]}

Lau, J. W. ^{[1
]}

Goernitz, E. ^{[5
]}

Gruettner, C. ^{[6
]}

机构：

[1] NIST, Mat Sci & Engn Lab, Gaithersburg, MD 20899 USA

[2] NIST, Ctr Neutron Res, Gaithersburg, MD 20899 USA

[3] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA

[4] Triton Biosyst Inc, Chelmsford, MA 01824 USA

[5] Fraunhofer Inst Angewandte Polymerforsch, D-14476 Potsdam, Germany

[6] Micromod Partikeltechnol GmbH, D-18119 Rostock, Germany

来源：

JOURNAL OF APPLIED PHYSICS | 2008年 / 103卷 / 07期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1063/1.2837647

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Magnetic nanoparticles with a high specific absorption rate (SAR) have been developed and used in mouse models of cancer. The magnetic nanoparticles are comprised of predominantly iron oxide magnetic cores surrounded by a dextran layer for colloidal stability. The average diameter of a single particle (core plus dextran) is 92 +/- 14 nm as measured by photon correlation spectroscopy. Small angle neutron scattering measurements under several H2O/D2O contrast conditions and at varying nanoparticle concentrations have revealed three length scales: >10 mu m, several hundred nanometers, and tens of nanometers. The latter corresponds to the particle diameter; the several hundred nanometers corresponds to a hard sphere interaction radius of the core/shell nanoparticles; >10 mu m corresponds to the formation of long-range, many-particle structures held together by magnetic interactions and dextran. The long-range collective magnetic behavior appears to play a major role in enhancing the SAR. For samples having nominally equal concentrations and similar saturation magnetizations, the measured SAR is 1075 W/(g of Fe) for tightly associated nanoparticles and 150 W/(g of Fe) for very loosely associated nanoparticles at an applied field of 86 kA/m (1080 Oe) and 150 kHz. (c) 2008 American Institute of Physics.

引用

页数：3

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