Ahch, the mouse homologue of DAX1: Cloning, characterization and synteny with GyK, the glycerol kinase locus

被引：24

作者：

Guo, WW

Lovell, RS

Zhang, YH

Huang, BL

Burris, TP

Craigen, WJ

McCabe, ERB

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT PEDIAT,LOS ANGELES,CA 90024

[2] BAYLOR COLL MED,DEPT MOL & HUMAN GENET,HOUSTON,TX 77030

来源：

GENE | 1996年 / 178卷 / 1-2期

关键词：

adrenal hypoplasia congenita; hypogonadotropic hypogonadism; Duchenne muscular dystrophy; steroidogenic factor 1 response element; dosage sensitive sex reversal locus; zinc-finger domain;

D O I：

10.1016/0378-1119(96)00320-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We cloned the murine full-length cDNA encoding Ahch, the mouse homologue of DAX1 (DSS-AHC Region on Human X Chromosome, Gene1) which is the gene responsible for human X-linked adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism (HH). Sequence analysis revealed that the murine and human cDNAs have 65% aa identity and 75% aa similarity overall. The cysteine residues in the putative DNA binding domain, which may interact with Zn2+ ions to form zinc fingers, are 100% conserved between the two species, indicating that the novel zinc-finger structures in DAX1 may be functional. In addition, mouse interspecific backcrosses show that the Ahch gene is closely linked to the glycerol kinase locus, GyK, on the mouse X chromosome, indicating that the order of the loci is conserved in this syntenic region between mouse and human.

引用

页码：31 / 34

页数：4

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