Euphosalicin, a new diterpene polyester with multidrug resistance reversing activity from Euphorbia salicifolia

被引：39

作者：

Hohmann, J ^{[1
]}

Evanics, F

Dombi, G

Szabó, P

机构：

[1] Univ Szeged, Dept Pharmacognosy, H-6720 Szeged, Hungary

[2] Univ Szeged, Dept Pharmaceut Anal, H-6720 Szeged, Hungary

[3] Univ Szeged, Dept Med Microbiol, H-6720 Szeged, Hungary

[4] Hungarian Acad Sci, Inst Chem, Chem Res Ctr, H-1525 Budapest, Hungary

来源：

TETRAHEDRON | 2001年 / 57卷 / 01期

基金：

匈牙利科学研究基金会;

关键词：

terpenes and terpenoids; esters; natural products; NMR;

D O I：

10.1016/S0040-4020(00)00982-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel diterpene polyester, named euphosalicin (1), the first representative of a new class of bicyclic diterpenes, was isolated from the dichloromethane extract of the whole plant of Euphorbia salicifolia, together with one known (2) and two new jatrophane diterpenes (3, 4). The new carbon skeleton is formally derived from the jatrophane framework by incorporation of a geminal methyl group in the ring system. Compound 1 was found to be more active than verapamil in reversing multidrug resistance in mouse lymphoma cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：211 / 215

页数：5

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