The non-separability of physiologic noise in functional connectivity MRI with spatial ICA at 3T

被引:29
作者
Beall, Erik B. [1 ]
Lowe, Mark J. [1 ]
机构
[1] Cleveland Clin, Imaging Inst, Cleveland, OH 44195 USA
关键词
Functional magnetic resonance imaging; Functional connectivity; Default mode network; Physiologic noise; Independent component analysis; Resting state networks; Default mode; Physiologic correction; Group ICA; INDEPENDENT COMPONENT ANALYSIS; BLIND SOURCE SEPARATION; RESTING-STATE NETWORKS; FMRI DATA; GLOBAL SIGNAL; MOTOR CORTEX; HUMAN BRAIN; FLUCTUATIONS; VISUALIZATION; ALGORITHMS;
D O I
10.1016/j.jneumeth.2010.06.024
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The impact of physiologic noise on spatial ICA analyses of resting state BOLD-weighted MRI data is investigated. Using FastICA and Infomax ICA, two common ICA algorithms, we apply a group spatial ICA method across multiple subjects. We compare the spatial maps from five commonly identified functional networks and show that physiologic noise correction techniques introduce significant changes in the spatial ICA decomposition of all five networks, greater than the changes introduced by either algorithmic indeterminacy (re-running ICA) or the changes introduced by decreasing the decomposition dimensionality due to physiologic noise removal. In addition, we demonstrate that the sources associated with these components have significant temporal correlation to parallel measures of cardiac and respiratory rates, and these are reduced after correction. We conclude that ICA decomposition is significantly affected by physiologic noise and the ICA process alone is not sufficient to separate physiologic noise effects in the brain. It is recommended that physiologic noise correction be applied to timeseries data prior to ICA decomposition. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:263 / 276
页数:14
相关论文
共 48 条
[1]  
ABOUELSEOUD A, 2010, HUM BRAIN MAPP
[2]   Independent component analysis applied to diffusion tensor MRI [J].
Arfanakis, K ;
Cordes, D ;
Haughton, VM ;
Carew, JD ;
Meyerand, ME .
MAGNETIC RESONANCE IN MEDICINE, 2002, 47 (02) :354-363
[3]  
BEALL EB, 2008, ANAL ROBUSTNESS RVT
[4]   Isolating physiologic noise sources with independently determined spatial measures [J].
Beall, Erik B. ;
Lowe, Mark J. .
NEUROIMAGE, 2007, 37 (04) :1286-1300
[5]   Adaptive cyclic physiologic noise modeling and correction in functional MRI [J].
Beall, Erik B. .
JOURNAL OF NEUROSCIENCE METHODS, 2010, 187 (02) :216-228
[6]   Tensorial extensions of independent component analysis for multisubject FMRI analysis [J].
Beckmann, CF ;
Smith, SM .
NEUROIMAGE, 2005, 25 (01) :294-311
[7]   Probabilistic independent component analysis for functional magnetic resonance imaging [J].
Beckmann, CF ;
Smith, SA .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 2004, 23 (02) :137-152
[8]   Investigations into resting-state connectivity using independent component analysis [J].
Beckmann, CF ;
DeLuca, M ;
Devlin, JT ;
Smith, SM .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2005, 360 (1457) :1001-1013
[9]   AN INFORMATION MAXIMIZATION APPROACH TO BLIND SEPARATION AND BLIND DECONVOLUTION [J].
BELL, AJ ;
SEJNOWSKI, TJ .
NEURAL COMPUTATION, 1995, 7 (06) :1129-1159
[10]   Cardiac-induced physiologic noise in tissue is a direct observation of cardiac-induced fluctuations [J].
Bhattacharyya, PK ;
Lowe, MJ .
MAGNETIC RESONANCE IMAGING, 2004, 22 (01) :9-13