Metal-catalyzed coupling reactions on an olefin template: the total synthesis of Bupleurynol

被引：20

作者：

Antunes, LM ^{[1
]}

Organ, MG ^{[1
]}

机构：

[1] York Univ, Dept Chem, Toronto, ON M3J 1P3, Canada

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 36期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4039(03)01753-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The naturally occurring polyacetylene Bupleurynol was synthesized in a convergent and stereospecific manner using a series of metal-mediated cross-coupling reactions. The synthesis demonstrates the utility of using a di-functional olefin template for the stereospecific synthesis of a disubstituted alkene product and its elaboration to a natural product target. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：6805 / 6808

页数：4

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