Microbial peptides and superantigens in the pathogenesis of autoimmune diseases of the central nervous system

被引:28
作者
Brocke, S
Hausmann, S
Steinman, L
Wucherpfennig, KW
机构
[1] NINDS, Neurol Dis Sect, NIB, NIH, Bethesda, MD 20892 USA
[2] Stanford Univ, Med Ctr, Beckman Ctr, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA
[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
microbial peptide antigens; superantigens; autoimmune disease;
D O I
10.1006/smim.1997.0105
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The mechanisms by which microbial peptide antigens and superantigens might initiate and perpetuate autoimmune responses against antigens of the central nervous system are discussed. A model will be proposed that includes the initial activation of naive T lymphocytes through T cell receptor-mediated recognition of microbial antigens presented by MHC class II molecules. This event might be followed by re-activation of autoreactive T cells by bacterial and viral superantigens. Bath mechanisms could lead to acute and relapsing autoimmune disease.
引用
收藏
页码:57 / 67
页数:11
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