Isotope dilution technique for quantitative analysis of endogenous trace element species in biological systems

被引：40

作者：

Schaumlöffel, D

Lobinski, R

机构：

[1] CNRS, UMR 5034, Grp Bioinorgan Analyt Chem, F-64053 Pau, France

[2] Warsaw Univ Technol, Dept Analyt Chem, PL-00664 Warsaw, Poland

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2005年 / 242卷 / 2-3期

关键词：

biomolecules; inductively coupled plasma mass spectrometry; isotope dilution technique; speciation;

D O I：

10.1016/j.ijms.2004.11.020

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

The recent developments and trends in quantitative speciation analysis of endogenous trace element compounds in biological systems by ICP isotope dilution MS are discussed. The use of two different isotope dilution techniques is critically evaluated with respect to their advantages and limitations: species-unspecific isotope dilution for the quantification of trace elements bound to unknown biomolecules and species-specific isotope dilution for the quantification of well-defined compounds. Recent data on the quantification of metallobiomolecules by isotope dilution analysis are summarized and future directions in this new field of analytical chemistry are highlighted. (c) 2004 Elsevier B.V. All rights reserved.

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页码：217 / 223

页数：7

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