Calcium and calmodulin in membrane fusion

被引:91
作者
Burgoyne, RD [1 ]
Clague, MJ [1 ]
机构
[1] Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2003年 / 1641卷 / 2-3期
关键词
calcium; calmodulin; endocytosis; exocytosis; membrane traffic; neurotransmission; SNARE; synapse;
D O I
10.1016/S0167-4889(03)00089-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Regulated exocytosis was the first intracellular membrane fusion step that was suggested to involve both Ca2+ and calmodulin. In recent years, it has become clear that calmodulin is not an essential Ca2+ sensor for exocytosis but that it is likely to have a more regulatory role. A requirement for cytosolic Ca2+ in other vesicle fusion events within cells has become apparent and in certain cases, such as homotypic fusion of early endosomes and yeast vacuoles, calmodulin may be the primary Ca2+ sensor. A number of distinct targets for calmodulin have been identified including SNARE proteins and subunits of the vacuolar ATPase. The extent to which calmodulin regulates different intracellular fusion events through conserved SNARE-dependent or other mechanisms remains to be resolved. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:137 / 143
页数:7
相关论文
共 87 条
[81]   Structure, function and regulation of the vacuolar (H+)-ATPase [J].
Stevens, TH ;
Forgac, M .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 :779-808
[82]   Synaptotagmins:: Why so many? [J].
Südhof, TC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (10) :7629-7632
[83]  
TEO TS, 1973, J BIOL CHEM, V248, P5950
[84]   A LOW-AFFINITY CA2+ RECEPTOR CONTROLS THE FINAL STEPS IN PEPTIDE SECRETION FROM PITUITARY MELANOTROPHS [J].
THOMAS, P ;
WONG, JG ;
LEE, AK ;
ALMERS, W .
NEURON, 1993, 11 (01) :93-104
[85]   Local Ca2+ release from internal stores controls exocytosis in pituitary gonadotrophs [J].
Tse, FW ;
Tse, A ;
Hille, B ;
Horstmann, H ;
Almers, W .
NEURON, 1997, 18 (01) :121-132
[86]   Rab3A and calmodulin regulate acrosomal exocytosis by mechanisms that do not require a direct interaction [J].
Yunes, R ;
Tomes, C ;
Michaut, M ;
De Blas, G ;
Rodriguez, F ;
Regazzi, R ;
Mayorga, LS .
FEBS LETTERS, 2002, 525 (1-3) :126-130
[87]   Calmodulin supports both inactivation and facilitation of L-type calcium channels [J].
Zühlke, RD ;
Pitt, GS ;
Deisseroth, K ;
Tsien, RW ;
Reuter, H .
NATURE, 1999, 399 (6732) :159-162