Rounding of aggregates of biological cells: Experiments and simulations

被引：59

作者：

Mombach, JCM

Robert, D

Graner, F

Gillet, G

Thomas, GL

Idiart, M

Rieu, JP

机构：

[1] Univ Vale Rio Sinos, Lab Bioinformat & Biol Computac, BR-93022000 Sao Leopoldo, RS, Brazil

[2] CNRS, UMR5586, Lab Phys Mat Condensee & Nanostruct, F-69623 Villeurbanne, France

[3] Univ Lyon 1, F-69623 Villeurbanne, France

[4] CNRS, UMR5588, Spectrometrie Phys Lab, F-38402 St Martin Dheres, France

[5] Univ Grenoble 1, F-38402 St Martin Dheres, France

[6] CNRS, Inst Biol & Chim Prot, F-69367 Lyon, France

[7] Univ Lyon 1, F-69367 Lyon, France

[8] Univ Fed Rio Grande Sul, Inst Fis, BR-91501970 Porto Alegre, RS, Brazil

来源：

PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS | 2005年 / 352卷 / 2-4期

关键词：

D O I：

10.1016/j.physa.2005.02.008

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The influence of surface tension and size on rounding of cell aggregates is studied using chick embryonic cells and numerical simulations based on the cellular Potts model. Our results show exponential relaxation in both cases as verified in previous studies using 2D Hydra cell aggregates. The relaxation time decreases with higher surface tension as expected from hydrodynamics laws. However, it increases faster than linearly with aggregate size. The results provide an additional support to the validity of the cellular Potts model for non-equilibrium situations and indicate that aggregate shape relaxation is not governed by the hydrodynamics of viscous liquids. © 2005 Elsevier B.V. All rights reserved.

引用

页码：525 / 534

页数：10