EGFR mutation conferring primary resistance to gefitinib in non-small-cell lung cancer

被引:142
作者
Shih, JY [1 ]
Gow, CH [1 ]
Yang, PC [1 ]
机构
[1] Natl Taiwan Univ Hosp, Taipei 100, Taiwan
关键词
D O I
10.1056/NEJM200507143530217
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:207 / 208
页数:2
相关论文
共 5 条
[1]   EGFR mutation and resistance of non-small-cell lung cancer to gefitinib [J].
Kobayashi, S ;
Boggon, TJ ;
Dayaram, T ;
Janne, PA ;
Kocher, O ;
Meyerson, M ;
Johnson, BE ;
Eck, MJ ;
Tenen, DG ;
Halmos, B .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (08) :786-792
[2]   Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib [J].
Lynch, TJ ;
Bell, DW ;
Sordella, R ;
Gurubhagavatula, S ;
Okimoto, RA ;
Brannigan, BW ;
Harris, PL ;
Haserlat, SM ;
Supko, JG ;
Haluska, FG ;
Louis, DN ;
Christiani, DC ;
Settleman, J ;
Haber, DA .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (21) :2129-2139
[3]   EGFR mutations in non-small-cell lung cancer:: Analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment [J].
Marchetti, A ;
Martella, C ;
Felicioni, L ;
Barassi, F ;
Salvatore, S ;
Chella, A ;
Camplese, PP ;
Iarussi, T ;
Mucilli, F ;
Mezzetti, A ;
Cuccurullo, F ;
Sacco, R ;
Buttitta, F .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (04) :857-865
[4]   Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain [J].
Pao, W ;
Miller, VA ;
Politi, KA ;
Riely, GJ ;
Somwar, R ;
Zakowski, MF ;
Kris, MG ;
Varmus, H .
PLOS MEDICINE, 2005, 2 (03) :225-235
[5]   Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways [J].
Sordella, R ;
Bell, DW ;
Haber, DA ;
Settleman, J .
SCIENCE, 2004, 305 (5687) :1163-1167