TLR ignores methylated RNA?

被引：39

作者：

Ishii, KJ

Akira, S

机构：

[1] Osaka Univ, JST, ERATO, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan

来源：

IMMUNITY | 2005年 / 23卷 / 02期

关键词：

D O I：

10.1016/j.immuni.2005.08.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CpG methylation of DNA silences TLR9-mediated innate immune recognition. In this issue of Immunity, Kariko et al. (2005) suggest that the innate immune recognition of RNA by TLR3, TLR7, or TLR8 is in fact controlled by modification of nucleotides, including methylation.

引用

收藏

页码：111 / 113

页数：3

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