Liquid-phase synthesis of 2-substituted benzimidazoles, benzoxazoles and benzothiazoles

被引：97

作者：

Chen, CP ^{[1
]}

Chen, YJ ^{[1
]}

机构：

[1] Natl Dong Hwa Univ, Dept Chem, Shoufeng 974, Hualien, Taiwan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 01期

关键词：

benzimidazole; benzoxazole; benzothiazole;

D O I：

10.1016/j.tetlet.2003.10.095

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel acid fluoride for use in the liquid-phase synthesis of substituted benzimidazoles, benzoxazoles and benzothiazoles was developed. Its synthetic utility is exemplified by a structurally diverse set of aromatic heterocycles. Final cleavage is achieved by treatment with sodium methoxide in methanol for 12 h. The corresponding benzimidazoles, benzoxazoles and benzothiazoles were obtained in good isolated yields (22-62%, four steps). (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：113 / 115

页数：3

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