Visfatin: the missing link between intra-abdominal obesity and diabetes?

被引：235

作者：

Sethi, JK ^{[1
]}

Vidal-Puig, A ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QR, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2005年 / 11卷 / 08期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.molmed.2005.06.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human obesity-related diabetes and the accompanying metabolic disorders have been specifically linked to increased visceral adipose tissue mass. Understanding the differences in biology of the two human fat depots (visceral and subcutaneous) might hold the key to therapeutic strategies aimed at reducing obesity-induced insulin resistance and alleviating symptoms of the metabolic syndrome. Visfatin (pre-B-cell colony-enhancing factor, PBEF) is a novel adipokine that appears to be preferentially produced by visceral adipose tissue and has insulin-mimetic actions. Could this molecule hold the key to future treatments for type 1 and 2 diabetes? This article discusses the pros and cons of visfatin action and how it might affect future therapeutic strategies.

引用

页码：344 / 347

页数：4

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