Impaired quality control of mitochondria: Aging from a new perspective

被引：90

作者：

Weber, Tobias A. ^{[1
]}

Reichert, Andreas S. ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, CEF Makromol Komplexe, Fachbereich Med, D-60590 Frankfurt, Germany

来源：

EXPERIMENTAL GERONTOLOGY | 2010年 / 45卷 / 7-8期

关键词：

Aging; Mitochondrial dysfunction; Fusion; Fission; Autophagy; Mitophagy; Sirtuins; Longevity; ROS; M-AAA PROTEASE; DOMINANT OPTIC ATROPHY; CALORIC RESTRICTION; SACCHAROMYCES-CEREVISIAE; OXIDATIVE STRESS; LIFE-SPAN; SKELETAL-MUSCLE; CELL-SURVIVAL; POINT MUTATIONS; DNA MUTATIONS;

D O I：

10.1016/j.exger.2010.03.018

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Mitochondria fulfill a number of essential cellular functions and play a key role in the aging process. Reactive oxygen species (ROS) are predominantly generated in this organelle but next to inducing oxidative damage they act as signaling molecules. Autophagy is regulated by signaling ROS and is known to affect aging as well as neurodegenerative diseases. Many cellular components that influence autophagy are linked to longevity such as members of the sirtuin protein family. Recent studies further link mitochondrial dynamics to the removal of dysfunctional mitochondria by mitophagy, thereby representing a novel mechanism for the quality control of mitochondria. Here we summarize the current views on how mitochondrial function is linked to aging and we propose that quality control of mitochondria has a crucial role in counteracting the aging process. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：503 / 511

页数：9

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