In search of phenotypes

被引：37

作者：

Bierma-Zeinstra, Sita M. ^{[1
,2
]}

van Middelkoop, Marienke ^{[1
]}

机构：

[1] Erasmus MC, Univ Med Ctr Rotterdam, Dept Gen Practice, POB 2040, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC, Univ Med Ctr Rotterdam, Dept Orthopaed, POB 2040, NL-3000 CA Rotterdam, Netherlands

来源：

NATURE REVIEWS RHEUMATOLOGY | 2017年 / 13卷 / 12期

关键词：

KNEE OSTEOARTHRITIS; PROGNOSTIC-FACTORS; METAANALYSIS; PROGRESSION; TRIALS;

D O I：

10.1038/nrrheum.2017.181

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Identifying different phenotypes of osteoarthritis is currently a subject of much research; however, a new systematic review has sparked discussion about the discrepancies in how research into disease phenotypes is conducted. Can we define individual phenotypes if we cannot agree on what constitutes a phenotype in the first place?

引用

页码：705 / 706

页数：2

共 9 条

[1]

What Are the Prognostic Factors for Radiographic Progression of Knee Osteoarthritis? A Meta-analysis [J].

Bastick, Alex N. ;

Belo, Janneke N. ;

Runhaar, Jos ;

Bierma-Zeinstra, Sita M. A. .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2015, 473 (09) :2969-2989

[2]

Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies [J].

Bastick, Alex N. ;

Runhaar, Jos ;

Belo, Janneke N. ;

Bierma-Zeinstra, Sita M. A. .

ARTHRITIS RESEARCH & THERAPY, 2015, 17

[3]

Osteoarthritis subpopulations and implications for clinical trial design [J].

Bierma-Zeinstra, Sita M. A. ;

Verhagen, Arianne P. .

ARTHRITIS RESEARCH & THERAPY, 2011, 13 (02)

[4]

Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature [J].

Dell'Isola, A. ;

Allan, R. ;

Smith, S. L. ;

Marreiros, S. S. P. ;

Steultjens, M. .

BMC MUSCULOSKELETAL DISORDERS, 2016, 17 :1-12

[5]

Deveza L. A., 2017, OSTEOARTHRITIS CARTI

[6]

Identifying different osteoarthritis phenotypes through epidemiology [J].

Felson, D. T. .

OSTEOARTHRITIS AND CARTILAGE, 2010, 18 (05) :601-604

[7]

OARSI Clinical Trials Recommendations: Design, conduct, and reporting of clinical trials for knee osteoarthritis [J].

McAlindon, T. E. ;

Driban, J. B. ;

Henrotin, Y. ;

Hunter, D. J. ;

Jiang, G-L ;

Skou, S. T. ;

Wang, S. ;

Schnitzer, T. .

OSTEOARTHRITIS AND CARTILAGE, 2015, 23 (05) :747-760

[8]

Credibility of claims of subgroup effects in randomised controlled trials: systematic review [J].

Sun, Xin ;

Briel, Matthias ;

Busse, Jason W. ;

You, John J. ;

Akl, Elie A. ;

Mejza, Filip ;

Bala, Malgorzata M. ;

Bassler, Dirk ;

Mertz, Dominik ;

Diaz-Granados, Natalia ;

Vandvik, Per Olav ;

Malaga, German ;

Srinathan, Sadeesh K. ;

Dahm, Philipp ;

Johnston, Bradley C. ;

Alonso-Coello, Pablo ;

Hassouneh, Basil ;

Walter, Stephen D. ;

Heels-Ansdell, Diane ;

Bhatnagar, Neera ;

Altman, Douglas G. ;

Guyatt, Gordon H. .

BMJ-BRITISH MEDICAL JOURNAL, 2012, 344

[9]

The OA Trial Bank: meta-analysis of individual patient data from knee and hip osteoarthritis trials show that patients with severe pain exhibit greater benefit from intra-articular glucocorticoids [J].

van Middelkoop, M. ;

Arden, N. K. ;

Atchia, I. ;

Birrell, F. ;

Chao, J. ;

Rezende, M. U. ;

Lambert, R. G. W. ;

Ravaud, P. ;

Bijlsma, J. W. ;

Doherty, M. ;

Dziedzic, K. S. ;

Lohmander, L. S. ;

McAlindon, T. E. ;

Zhang, W. ;

Bierma-Zeinstra, S. M. A. .

OSTEOARTHRITIS AND CARTILAGE, 2016, 24 (07) :1143-1152

← 1 →