Neuroimaging in Alzheimer disease: An evidence-based review

被引:140
作者
Kantarci, K [1 ]
Jack, CR [1 ]
机构
[1] Mayo Clin & Mayo Fdn, Dept Radiol, Rochester, MN 55905 USA
关键词
D O I
10.1016/S1052-5149(03)00025-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Alzheimer disease (AD) is the most prevalent of dementia syndromes. The number of elderly individuals affected with the disease is expected to grow with increasing life expectancy. There is no definite biomarker available for the diagnosis of AD; clinical criteria are currently used. Neuroimaging can identify potentially treatable causes of dementia, and it is also sensitive to the early structural and functional changes in the brains of patients with AD. This article reviews the evidence on the usefulness of neuroimaging in clinical evaluation of AD and as a surrogate marker for early detection and disease progression.
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页码:197 / +
页数:60
相关论文
共 97 条
[81]  
Price JL, 1999, ANN NEUROL, V45, P358, DOI 10.1002/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO
[82]  
2-X
[83]   Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E [J].
Reiman, EM ;
Caselli, RJ ;
Yun, LS ;
Chen, KW ;
Bandy, D ;
Minoshima, S ;
Thibodeau, SN ;
Osborne, D .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (12) :752-758
[84]   Declining brain activity in cognitively normal apolipoprotein E ε4 heterozygotes:: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease [J].
Reiman, EM ;
Caselli, RJ ;
Chen, KW ;
Alexander, GE ;
Bandy, D ;
Frost, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (06) :3334-3339
[85]   A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease [J].
Rogers, SL ;
Farlow, MR ;
Doody, RS ;
Mohs, R ;
Friedhoff, LT ;
Albala, B ;
Baumel, B ;
Booker, G ;
Dexter, J ;
Farmer, M ;
Feighner, JP ;
Ferris, S ;
Gordon, B ;
Gorman, DG ;
Hanna, G ;
Harrell, LE ;
Hubbard, R ;
Kennedy, J ;
McCarthy, J ;
Scharre, DW ;
Schaerf, F ;
Schneider, L ;
Seltzer, B ;
Siegal, A ;
Stark, SR ;
Strauss, A ;
Walshe, TM .
NEUROLOGY, 1998, 50 (01) :136-145
[86]   Preclinical AD revisited - Neuropathology of cognitively normal older adults [J].
Schmitt, FA ;
Davis, DG ;
Wekstein, DR ;
Smith, CD ;
Ashford, JW ;
Markesbery, WR .
NEUROLOGY, 2000, 55 (03) :370-376
[87]   PROBABLE ALZHEIMER-DISEASE - DIAGNOSIS WITH PROTON MR SPECTROSCOPY [J].
SHONK, TK ;
MOATS, RA ;
GIFFORD, P ;
MICHAELIS, T ;
MANDIGO, JC ;
IZUMI, J ;
ROSS, BD .
RADIOLOGY, 1995, 195 (01) :65-72
[88]   Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease [J].
Small, GW ;
Ercoli, LM ;
Silverman, DHS ;
Huang, SC ;
Komo, S ;
Bookheimer, SY ;
Lavretsky, H ;
Miller, K ;
Siddarth, P ;
Rasgon, NL ;
Mazziotta, JC ;
Saxena, S ;
Wu, HM ;
Mega, MS ;
Cummings, JL ;
Saunders, AM ;
Pericak-Vance, MA ;
Roses, AD ;
Barrio, JR ;
Phelps, ME .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (11) :6037-6042
[89]   APOLIPOPROTEIN-E TYPE-4 ALLELE AND CEREBRAL GLUCOSE-METABOLISM IN RELATIVES AT RISK FOR FAMILIAL ALZHEIMER-DISEASE [J].
SMALL, GW ;
MAZZIOTTA, JC ;
COLLINS, MT ;
BAXTER, LR ;
PHELPS, ME ;
MANDELKERN, MA ;
KAPLAN, A ;
LARUE, A ;
ADAMSON, CF ;
CHANG, L ;
GUZE, BH ;
CORDER, EH ;
SAUNDERS, AM ;
HAINES, JL ;
PERICAKVANCE, MA ;
ROSES, AD .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 273 (12) :942-947
[90]   TOPOGRAPHY OF CROSS-SECTIONAL AND LONGITUDINAL GLUCOSE METABOLIC DEFICITS IN ALZHEIMERS-DISEASE - PATHOPHYSIOLOGIC IMPLICATIONS [J].
SMITH, GS ;
DELEON, MJ ;
GEORGE, AE ;
KLUGER, A ;
VOLKOW, ND ;
MCRAE, T ;
GOLOMB, J ;
FERRIS, SH ;
REISBERG, B ;
CIARAVINO, J ;
LAREGINA, ME .
ARCHIVES OF NEUROLOGY, 1992, 49 (11) :1142-1150