Calcium signalling in lymphocyte activation and disease

被引：810

作者：

Feske, Stefan ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 09期

关键词：

D O I：

10.1038/nri2152

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Calcium signals in cells of the immune system participate in the regulation of cell differentiation, gene transcription and effector functions. An increase in intracellular levels of calcium ions (Ca2+) results from the engagement of immunoreceptors, such as the T-cell receptor, B-cell receptor and Fc receptors, as well as chemokine and co-stimulatory receptors. The major pathway that induces an increase in intracellular Ca2+ levels in lymphocytes is through store-operated calcium entry (SOCE) and calcium-release activated calcium ( CRAC) channels. This Review focuses on the role of Ca2+ signals in lymphocyte functions, the signalling pathways leading to Ca2+ influx, the function of the recently discovered regulators of Ca2+ influx (STIM and ORAI), and the relationship between Ca2+ signals and diseases of the immune system.

引用

页码：690 / 702

页数：13

共 137 条

[11] The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1
Bléry, M
Kubagawa, H
Chen, CC
Vély, F
Cooper, MD
Vivier, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) : 2446 - 2451
[12] Spontaneous autoimmune disease in FcγRIIB-deficient mice results from strain-specific epistasis
Bolland, S
Ravetch, JV
[J]. IMMUNITY, 2000, 13 (02) : 277 - 285
[13] Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution
Buckley, RH
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 2004, 22 : 625 - 655
[14] Molecular properties and physiological roles of ion channels in the immune system
Cahalan, MD
Wulff, H
Chandy, KG
[J]. JOURNAL OF CLINICAL IMMUNOLOGY, 2001, 21 (04) : 235 - 252
[15] CD19 - LOWERING THE THRESHOLD FOR ANTIGEN RECEPTOR STIMULATION OF LYMPHOCYTES-B
CARTER, RH
FEARON, DT
[J]. SCIENCE, 1992, 256 (5053) : 105 - 107
[16] K+ channels as targets for specific immunomodulation
Chandy, KG
Wulff, H
Beeton, C
Pennington, M
Gutman, GA
Cahalan, MD
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2004, 25 (05) : 280 - 289
[17] Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome
Cianferoni, A
Massaad, M
Feske, S
de la Fuente, MA
Gallego, L
Ramesh, N
Geha, RS
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (06) : 1364 - 1371
[18] Sorting out MIC, TRP, and CRAC ion channels
Clapham, DE
[J]. JOURNAL OF GENERAL PHYSIOLOGY, 2002, 120 (02) : 217 - 220
[19] Requirement for the leukocyte-specific adapter protein SLP-76 for normal T-cell development
Clements, JL
Yang, B
Ross-Barta, SE
Eliason, SL
Hrstka, RF
Williamson, RA
Koretzky, GA
[J]. SCIENCE, 1998, 281 (5375) : 416 - 419
[20] EXTENT OF T-CELL RECEPTOR LIGATION CAN DETERMINE THE FUNCTIONAL-DIFFERENTIATION OF NAIVE CD4(+) T-CELLS
CONSTANT, S
PFEIFFER, C
WOODARD, A
PASQUALINI, T
BOTTOMLY, K
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (05) : 1591 - 1596

← 1 2 3 4 5 6 7 8 9 10 →