Calcium signalling in lymphocyte activation and disease

被引:810
作者
Feske, Stefan [1 ]
机构
[1] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA
关键词
D O I
10.1038/nri2152
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Calcium signals in cells of the immune system participate in the regulation of cell differentiation, gene transcription and effector functions. An increase in intracellular levels of calcium ions (Ca2+) results from the engagement of immunoreceptors, such as the T-cell receptor, B-cell receptor and Fc receptors, as well as chemokine and co-stimulatory receptors. The major pathway that induces an increase in intracellular Ca2+ levels in lymphocytes is through store-operated calcium entry (SOCE) and calcium-release activated calcium ( CRAC) channels. This Review focuses on the role of Ca2+ signals in lymphocyte functions, the signalling pathways leading to Ca2+ influx, the function of the recently discovered regulators of Ca2+ influx (STIM and ORAI), and the relationship between Ca2+ signals and diseases of the immune system.
引用
收藏
页码:690 / 702
页数:13
相关论文
共 137 条
  • [11] The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1
    Bléry, M
    Kubagawa, H
    Chen, CC
    Vély, F
    Cooper, MD
    Vivier, E
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) : 2446 - 2451
  • [12] Spontaneous autoimmune disease in FcγRIIB-deficient mice results from strain-specific epistasis
    Bolland, S
    Ravetch, JV
    [J]. IMMUNITY, 2000, 13 (02) : 277 - 285
  • [13] Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution
    Buckley, RH
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 2004, 22 : 625 - 655
  • [14] Molecular properties and physiological roles of ion channels in the immune system
    Cahalan, MD
    Wulff, H
    Chandy, KG
    [J]. JOURNAL OF CLINICAL IMMUNOLOGY, 2001, 21 (04) : 235 - 252
  • [15] CD19 - LOWERING THE THRESHOLD FOR ANTIGEN RECEPTOR STIMULATION OF LYMPHOCYTES-B
    CARTER, RH
    FEARON, DT
    [J]. SCIENCE, 1992, 256 (5053) : 105 - 107
  • [16] K+ channels as targets for specific immunomodulation
    Chandy, KG
    Wulff, H
    Beeton, C
    Pennington, M
    Gutman, GA
    Cahalan, MD
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2004, 25 (05) : 280 - 289
  • [17] Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome
    Cianferoni, A
    Massaad, M
    Feske, S
    de la Fuente, MA
    Gallego, L
    Ramesh, N
    Geha, RS
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (06) : 1364 - 1371
  • [18] Sorting out MIC, TRP, and CRAC ion channels
    Clapham, DE
    [J]. JOURNAL OF GENERAL PHYSIOLOGY, 2002, 120 (02) : 217 - 220
  • [19] Requirement for the leukocyte-specific adapter protein SLP-76 for normal T-cell development
    Clements, JL
    Yang, B
    Ross-Barta, SE
    Eliason, SL
    Hrstka, RF
    Williamson, RA
    Koretzky, GA
    [J]. SCIENCE, 1998, 281 (5375) : 416 - 419
  • [20] EXTENT OF T-CELL RECEPTOR LIGATION CAN DETERMINE THE FUNCTIONAL-DIFFERENTIATION OF NAIVE CD4(+) T-CELLS
    CONSTANT, S
    PFEIFFER, C
    WOODARD, A
    PASQUALINI, T
    BOTTOMLY, K
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (05) : 1591 - 1596