Synthesis of 13C3, 15N4-labeled factor Xa inhibitor

被引：12

作者：

Guilford, WJ ^{[1
]}

Dallas, J ^{[1
]}

Arnaiz, D ^{[1
]}

机构：

[1] Berlex Biosci, Med Chem, Richmond, CA 94804 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2001年 / 44卷 / 04期

关键词：

factor Xa inhibitor; ZK 807834 (CI 1031); mass label; tetralabeled N-methyl ethylenediamine;

D O I：

10.1002/jlcr.452

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of an isotopically-labeled, diphenoxypyridine factor Xa inhibitor, 3-[[6-[3-(4,5-dihydro-1-(C-13)-methyl-1H-(4-C-13, N-15(2)-imidazol-2-yl)phenoxy)-3,5-difluoro-4-(4-morpholinyl)-2-pyridinyl]oxy]-4-hydroxybenzene-C-13-carbox-N-15-imid-N-15-amide, is reported for use in factor Xa binding studies using REDOR NMR. N-benzyl protected tetralabeled N-methylethylene diamine was an intermediate in the preparation of 3-[4,5-1-(C-13)-methyl-1H-(4-C-13, N-15(2)-imidazol-2-yl)]phenol.

引用

页码：247 / 256

页数：10

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