Methylenetetrahydrofolate reductase C677T genotype and PD

被引：44

作者：

de Lau, LML

Koudstaal, PJ

van Meurs, JBJ

Uitterlinden, AG

Hofman, A

Breteler, MMB

机构：

[1] Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands

[2] Erasmus MC, Dept Neurol, NL-3000 DR Rotterdam, Netherlands

[3] Erasmus MC, Dept Internal Med, NL-3000 DR Rotterdam, Netherlands

来源：

ANNALS OF NEUROLOGY | 2005年 / 57卷 / 06期

关键词：

D O I：

10.1002/ana.20509

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In a prospective, population-based cohort study among 5,920 participants aged 55 years or older, we observed that the TT variant of the methylenetetrahydrofolate reductase C677T polymorphism is associated with an increased risk for Parkinson's disease in smokers. Both smoking and the TT genotype are known to induce hyperhomocystinemia, and synergistic effects on homocysteine levels have been reported. Increased plasma levels of homocysteine through direct neurotoxic effects might accelerate the selective dopaminergic cell death underlying Parkinson's disease. Our findings support the hypothesis that homocysteine plays a role in the pathogenesis of Parkinson's disease.

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页码：927 / 930

页数：4

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