Systems biology in neuroscience: bridging genes to cognition

被引：33

作者：

Grant, SGN ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Div Neurosci, Cambridge, England

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2003年 / 13卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.conb.2003.09.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Systems biology is a new branch of biology aimed at understanding biological complexity. Genomic and proteomic methods integrated with cellular and organismal analyses allow modelling of physiological processes. Progress in understanding synapse composition and new experimental and bioinformatics methods indicate the synapse is an excellent starting point for global systems biology of the brain. A neuroscience systems biology programme, organized as a consortium, is proposed.

引用

页码：577 / 582

页数：6

共 45 条

[1] Mass spectrometry-based proteomics [J].

Aebersold, R ;

Mann, M .

NATURE, 2003, 422 (6928) :198-207

[2]

[Anonymous], NEUROSCIENCE DATABAS

[3]

Barabasi A.L., 2002, The formula: the universal laws of success

[4] Emergence of scaling in random networks [J].

Barabási, AL ;

Albert, R .

SCIENCE, 1999, 286 (5439) :509-512

[5] Synaptic multiprotein complexes associated with 5-HT2C receptors:: a proteomic approach [J].

Bécamel, C ;

Alonso, G ;

Geléotti, N ;

Demey, E ;

Jouin, P ;

Ullmer, C ;

Dumuis, A ;

Bockaert, J ;

Marin, P .

EMBO JOURNAL, 2002, 21 (10) :2332-2342

[6]

Bertalanffy, 1969, GEN SYSTEM THEORY FD

[7]

BOLLOBAAS B, 1985, RANDOM GRAPHS

[8]

Buchanan Mark., 2002, NEXUS SMALL WORLDS G

[9] The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI [J].

Bussey, H ;

Storms, RK ;

Ahmed, A ;

Albermann, K ;

Allen, E ;

Ansorge, W ;

Araujo, R ;

Aparicio, A ;

Barrell, B ;

Badcock, K ;

Benes, V ;

Botstein, D ;

Bowman, S ;

Bruckner, M ;

Carpenter, J ;

Cherry, JM ;

Chung, E ;

Churcher, C ;

Coster, F ;

Davis, K ;

Davis, RW ;

Dietrich, FS ;

Delius, H ;

DiPaolo, T ;

Dubois, E ;

Dusterhoft, A ;

Duncan, M ;

Floeth, M ;

Fortin, N ;

Friesen, JD ;

Fritz, C ;

Goffeau, A ;

Hall, J ;

Hebling, U ;

Heumann, K ;

Hilbert, H ;

Hillier, L ;

HunickeSmith, S ;

Hyman, R ;

Johnston, M ;

Kalman, S ;

Kleine, K ;

Komp, C ;

Kurdi, O ;

Lashkari, D ;

Lew, H ;

Lin, A ;

Lin, D ;

Louis, EJ ;

Marathe, R .

NATURE, 1997, 387 (6632) :103-105

[10] Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice [J].

de Boer, E ;

Rodriguez, P ;

Bonte, E ;

Krijgsveld, J ;

Katsantoni, E ;

Heck, A ;

Grosveld, F ;

Strouboulis, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (13) :7480-7485

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