GLYCOSIDES FROM VALLARIS SOLANACEAE WITH TRAIL-RESISTANCE-OVERCOMING ACTIVITY

被引：12

作者：

Ahmed, Firoj ^{[1
]}

Sadhu, Samir Kumar ^{[1
,2
]}

Ohtsuki, Takashi ^{[1
]}

Khatun, Amina ^{[2
]}

Ishibashi, Masami ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

[2] Khulna Univ, Sch Life Sci, Pharm Discipline, Khulna 9208, Bangladesh

来源：

HETEROCYCLES | 2010年 / 80卷 / 01期

基金：

日本学术振兴会;

关键词：

Glycoside; Vallaris solanaceae; Cytotoxicity; TRAIL; CERBERA-MANGHAS; DIE GLYKOSIDE; UP-REGULATION; CANCER-CELLS; LUNG-CANCER; APOPTOSIS; CARDENOLIDES; ACTIVATION; CYTOTOXICITY; MECHANISMS;

D O I：

10.3987/COM-09-S(S)52

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new cardenolide glycoside, vallarisoside (1), and a known one, 3 beta-O-(alpha-acofriosyl)-l6-anhydrogitoxigenin (2) along with a new glycoside, benzyl 2-O-beta-apiofuranosyl-(1 -> 2)-beta-D-glucopyranosyl-2, 6-dihydroxy-benzoate (3) were isolated from Vallaris solanaceae. Structures of the isolates were elucidated by 1D and 2D NMR and mass spectroscopic analysis. Of the isolates, vallarisoside (1) showed potent TRAIL-resistance-overcoming activity in human gastric adenocarcinoma (AGS) cells and cell-growth-inhibitory activity against HeLa and SW480 cells.

引用

页码：477 / 488

页数：12

共 31 条

[21]

MASAHIKO H, 1987, J INTERFERON RES, V7, P419

[22] Activation of the S phase DNA damage checkpoint by mitomycin C [J].

Mladenov, Emil ;

Tsaneva, Irina ;

Anachkova, Boyka .

JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 211 (02) :468-476

[23] Steroidal saponins from Calamus insignis, and their cell growth and cell cycle inhibitory activities [J].

Ohtsuki, T ;

Sato, M ;

Koyano, T ;

Kowithayakorn, T ;

Kawahara, N ;

Goda, Y ;

Ishibashi, M .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (03) :659-665

[24] CARDENOLIDES OF CRYPTOSTEGIA-MADAGASCARIENSIS [J].

SANDUJA, R ;

LO, WYR ;

EULER, KL ;

ALAM, M ;

MORTON, JF .

JOURNAL OF NATURAL PRODUCTS, 1984, 47 (02) :260-265

[25] Enhancement of therapeutic potential of TRAIL by cancer chemotherapy and irradiation: mechanisms and clinical implications [J].

Shankar, S ;

Srivastava, RK .

DRUG RESISTANCE UPDATES, 2004, 7 (02) :139-156

[26] Cardenolides from the methanolic extract of Nerium oleander leaves possessing central nervous system depressant activity in mice [J].

Siddiqui, BS ;

Sultana, R ;

Begum, S ;

Zia, A ;

Suria, A .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (06) :540-544

[27] TRAIL/Apo-2L: Mechanisms and clinical applications in cancer [J].

Srivastava, RK .

NEOPLASIA, 2001, 3 (06) :535-546

[28] Novel phenylpropanoids and lignans from Illicium verum [J].

Sy, LK ;

Brown, GD .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (08) :987-992

[29]

TORI K, 1973, TETRAHEDRON LETT, V35, P1077

[30] CHEMISTRY OF APIOSE .I. [J].

WILLIAMS, DT ;

JONES, JKN .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1964, 42 (01) :69-&

← 1 2 3 4 →