Interleukin-18 produced by peripheral blood cells is increased in Alzheimer's disease and correlates with cognitive impairment

被引：97

作者：

Bossu, Paola ^{[1
]}

Ciaramella, Antonio ^{[1
]}

Salani, Francesca ^{[1
]}

Bizzoni, Federica ^{[1
]}

Varsi, Erika ^{[1
]}

Di Julio, Fulvia ^{[1
]}

Giubilei, Franco ^{[2
,3
]}

Gianni, Walter

Trequattrini, Alberto

Moro, Maria Luisa ^{[1
]}

Bernardini, Sergio ^{[4
,5
]}

Caltagirone, Carlo ^{[1
,6
]}

Spalletta, Gianfranco ^{[1
,7
]}

机构：

[1] IRCCS, Santa Lucia Fdn, Dept Clin & Behav Neurol, I-00179 Rome, Italy

[2] Univ Roma La Sapienza, Dept Neurol, Rome, Italy

[3] IRCCS, INRCA, Rome, Italy

[4] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy

[5] Univ Roma Tor Vergata, Dept Lab Med, Rome, Italy

[6] Univ Roma Tor Vergata, Dept Neurosci, Rome, Italy

[7] Univ Roma Tor Vergata, Tor Vergata Hosp, Neuropsychol Outpatient Clin, Rome, Italy

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2008年 / 22卷 / 04期

关键词：

interleukin-18; Alzheimer's disease; cognitive decline;

D O I：

10.1016/j.bbi.2007.10.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

A body of evidence indicates that inflammation plays a pivotal role in AD pathogenesis. IL-18 is a pro-inflammatory cytokine produced in the brain, emerging to be implicated in AD. Although no differences in circulating IL-18 levels were measured between AD patients and controls, a significant increased production of IL-18 was obtained from stimulated blood mononuclear cells of AD patients. This was true particularly in AD subjects carrying the C/C genotype at the -607 position of IL-18 gene promoter. Furthermore, a significant correlation between IL-18 production and cognitive decline was observed in AD patients. Overall, these data indicate that IL-18-related inflammatory pathways, probably also in virtue of polymorphic IL-18 gene influence, are exacerbated in AD patients, and that this cytokine may indeed participate in pathogenic processes leading to dementia. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：487 / 492

页数：6

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