NLRP3 inflammasomes link inflammation and metabolic disease

被引：489

作者：

De Nardo, Dominic ^{[1
]}

Latz, Eicke ^{[1
,2
]}

机构：

[1] Univ Bonn, Inst Innate Immun, Univ Hosp, Biomed Ctr, D-5300 Bonn, Germany

[2] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA

来源：

TRENDS IN IMMUNOLOGY | 2011年 / 32卷 / 08期

关键词：

INDUCED INSULIN-RESISTANCE; HUMAN ADIPOSE-TISSUE; TOLL-LIKE RECEPTOR; NALP3; INFLAMMASOME; INNATE IMMUNITY; TNF-ALPHA; PATHOPHYSIOLOGICAL CONCENTRATIONS; PATTERN-RECOGNITION; ACTIVATION; OBESITY;

D O I：

10.1016/j.it.2011.05.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-10 family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.

引用

页码：373 / 379

页数：7

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