Convergent synthesis of peptide nucleic acids by native chemical Ligation

被引：50

作者：

Dose, C ^{[1
]}

Seitz, O ^{[1
]}

机构：

[1] Humboldt Univ, Inst Chem, D-12489 Berlin, Germany

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 20期

关键词：

D O I：

10.1021/ol051489+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

graph A convergent strategy for synthesizing long contiguous PNA by a native chemical ligation-like technique of PNA segment couplings is presented. This approach required the synthesis of a new PNA-monomer featuring a 1-amino-2-thiol group. It is shown that the additional mercaptomethyl group leaves the hybridization properties of PNA ligation products unaffected. Furthermore, rapid and efficient fluorescence labeling of the ligation products is demonstrated.

引用

收藏

页码：4365 / 4368

页数：4

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