Reactivity of PNA thioesters in chemical ligation reactions

被引：2

作者：

de Koning, MC ^{[1
]}

van der Knaap, M ^{[1
]}

Petersen, L ^{[1
]}

van den Elst, H ^{[1
]}

van der Marel, GA ^{[1
]}

Overhand, M ^{[1
]}

Filippov, DV ^{[1
]}

机构：

[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands

来源：

SYNLETT | 2005年 / 04期

关键词：

native chemical ligation; thioesters; peptide nucleic acid; reactivity; convergent synthesis;

D O I：

10.1055/s-2005-863711

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The ligation rate and efficiency of PNA thioesters in the reaction with the pentapeptide CRYNK has been determined and proved to be substantially lower in comparison with the corresponding C-terminal glycine thioester.

引用

页码：595 / 598

页数：4

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