Synthetic developments towards PNA-peptide conjugates

被引：30

作者：

de Koning, MC ^{[1
]}

van der Marel, GA ^{[1
]}

Overhand, M ^{[1
]}

机构：

[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2003年 / 7卷 / 06期

关键词：

D O I：

10.1016/j.cbpa.2003.10.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the discovery of peptide nucleic acids (PNAs) as DNA mimics in the early 1990s, a tremendous effort has been directed to their application as antisense and antigene probes. With the aim of further enhancing their properties, PNAs have been conjugated to a variety of effector molecules. Among these, small peptide fragments, often derived from functional proteins, are able to convey their specific properties to the conjugate.

引用

页码：734 / 740

页数：7

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