Synthetic developments towards PNA-peptide conjugates

被引：30

作者：

de Koning, MC ^{[1
]}

van der Marel, GA ^{[1
]}

Overhand, M ^{[1
]}

机构：

[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2003年 / 7卷 / 06期

关键词：

D O I：

10.1016/j.cbpa.2003.10.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the discovery of peptide nucleic acids (PNAs) as DNA mimics in the early 1990s, a tremendous effort has been directed to their application as antisense and antigene probes. With the aim of further enhancing their properties, PNAs have been conjugated to a variety of effector molecules. Among these, small peptide fragments, often derived from functional proteins, are able to convey their specific properties to the conjugate.

引用

页码：734 / 740

页数：7

共 34 条

[11]

de Koning MC, 2001, SYNLETT, P1516

[12] Peptide nucleic acids: versatile tools for gene therapy strategies [J].

Dean, DA .

ADVANCED DRUG DELIVERY REVIEWS, 2000, 44 (2-3) :81-95

[13] PNA HYBRIDIZES TO COMPLEMENTARY OLIGONUCLEOTIDES OBEYING THE WATSON-CRICK HYDROGEN-BONDING RULES [J].

EGHOLM, M ;

BUCHARDT, O ;

CHRISTENSEN, L ;

BEHRENS, C ;

FREIER, SM ;

DRIVER, DA ;

BERG, RH ;

KIM, SK ;

NORDEN, B ;

NIELSEN, PE .

NATURE, 1993, 365 (6446) :566-568

[14] Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues [J].

Gait, MJ .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2003, 60 (05) :844-853

[15] Bactericidal antisense effects of peptide-PNA conjugates [J].

Good, L ;

Awasthi, SK ;

Dryselius, R ;

Larsson, O ;

Nielsen, PE .

NATURE BIOTECHNOLOGY, 2001, 19 (04) :360-364

[16]

Gottschling D, 2000, LETT PEPT SCI, V7, P35

[17] Anti-TAR polyamide nucleotide analog conjugated with a membrane-permeating peptide inhibits human immunodeficiency virus type 1 production [J].

Kaushik, N ;

Basu, A ;

Palumbo, P ;

Myers, RL ;

Pandey, VN .

JOURNAL OF VIROLOGY, 2002, 76 (08) :3881-3891

[18] Cell-dependent differential cellular uptake of PNA, peptides, and PNA-peptide conjugates [J].

Koppelhus, U ;

Awasthi, SK ;

Zachar, V ;

Holst, HU ;

Ebbesen, P ;

Nielsen, PE .

ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, 2002, 12 (02) :51-63

[19] Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression:: Preparation, characterization, and in vitro mRNA binding [J].

Lewis, MR ;

Jia, F ;

Gallazzi, F ;

Wang, Y ;

Zhang, JL ;

Shenoy, N ;

Lever, SZ ;

Hannink, M .

BIOCONJUGATE CHEMISTRY, 2002, 13 (06) :1176-1180

[20] Signal peptide mimics conjugated to peptide nucleic acid: A promising solution for improving cell membrane permeability [J].

Li, XX ;

Zhang, LR ;

Lu, JF ;

Chen, YZ ;

Min, JM ;

Zhang, LH .

BIOCONJUGATE CHEMISTRY, 2003, 14 (01) :153-157

← 1 2 3 4 →