Transactivation of an inducible anti-oxidative stress protein, human thioredoxin by HTLV-I Tax

被引：60

作者：

Masutani, H ^{[1
]}

Hirota, K ^{[1
]}

Sasada, T ^{[1
]}

UedaTaniguchi, Y ^{[1
]}

Taniguchi, Y ^{[1
]}

Sono, H ^{[1
]}

Yodoi, J ^{[1
]}

机构：

[1] KYOTO UNIV, INST VIRUS RES, SAKYO KU, KYOTO 60601, JAPAN

来源：

IMMUNOLOGY LETTERS | 1996年 / 54卷 / 2-3期

关键词：

adult T-cell leukemia-derived factor thioredoxin; redox regulation; oxidative stress; Tax; human T-cell lymphotropic virus type I (HTLV-I);

D O I：

10.1016/S0165-2478(96)02651-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Adult T-cell leukemia derived factor (ADF)/human thioredoxin (TRX), which has thiol reducing and radical scavenging activities, plays an essential role on cellular protection against oxidative stress and cell death. TRX itself is induced by various oxidative stress as well as the Human T-cell lymphotropic virus type I (HTLV-I) Tax protein. To investigate the mechanism of this induction, the promoter region of the TRX gene was analyzed. Chloramphenicol acetyltransferase (CAT) reporter constructs containing the TRX promoter sequences responded to the overexpression of the Tax protein, whereas various oxidative agents activated the TRX promoter through a newly identified oxidative responsive element. Moreover, TRX was translocated from the cytoplasm into the nucleus by ultraviolet irradiation, suggesting its possible role on sensing and transducing oxidative signals. (C) 1996 Elsevier Science B.V.

引用

页码：67 / 71

页数：5

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