Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu

被引：243

作者：

De Greve, J. ^{[1
]}

Teugels, E. ^{[1
]}

Geers, C. ^{[1
]}

Decoster, L. ^{[1
]}

Galdermans, D. ^{[2
]}

De Mey, J. ^{[1
]}

Everaert, H. ^{[1
]}

Umelo, I. ^{[1
]}

In't Veld, P. ^{[1
]}

Schallier, D. ^{[1
]}

机构：

[1] UZ Brussel, Ctr Oncol, B-1090 Brussels, Belgium

[2] ZNA Middelheim, Antwerp, Belgium

来源：

LUNG CANCER | 2012年 / 76卷 / 01期

关键词：

Non-small cell lung cancer (NSCLC); Epidermal growth factor receptor (EGFR); Human epidermal growth factor receptor 2 (HER2); Afatinib; Adenocarcinoma; Mutation; CANCER; GENE; GEFITINIB; THERAPY; TUMORS; EGFR;

D O I：

10.1016/j.lungcan.2012.01.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human epidermal growth factor receptor (HER)2/neu kinase domain mutations are found in approximately 1-4% of lung adenocarcinomas with a similar phenotype to tumors with epidermal growth factor receptor (EGFR) mutations. Afatinib is a potent irreversible ErbB family blocker. We determined the tumor genomic status of the EGFR and HER2 genes in non- or light smokers with lung adenocarcinoma in patients who were entered into an exploratory Phase II study with afatinib. Five patients with a nonsmoking history and metastatic lung adenocarcinomas bearing mutations in the kinase domain of HER2 gene were identified, three of which were evaluable for response. Objective response was observed in all three patients, even after failure of other EGFR- and/or HER2-targeted treatments: the case histories of these patients are described in this report. These findings suggest that afatinib is a potential novel treatment option for this subgroup of patients, even when other EGFR and HER2 targeting treatments have failed. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：123 / 127

页数：5

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