'Compulsive' lever pressing in rats is enhanced following lesions to the orbital cortex, but not to the basolateral nucleus of the amygdala or to the dorsal medial prefrontal cortex

被引:42
作者
Joel, D [1 ]
Doljansky, J [1 ]
Schiller, D [1 ]
机构
[1] Tel Aviv Univ, Dept Psychol, IL-69978 Tel Aviv, Israel
关键词
animal model; conditioned reinforcement; obsessive-compulsive disorder (OCD); orbitofrontal cortex; reinforcer devaluation; signal attenuation;
D O I
10.1111/j.1460-9568.2005.04042.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In a new rat model of obsessive-compulsive disorder (OCD), 'compulsive' behaviour is induced by attenuating a signal indicating that a lever-press response was effective in producing food. We have recently found that compulsive lever pressing is increased following lesions to the rat orbital cortex, in accordance with several lines of evidence implicating the orbitofrontal cortex in the pathophysiology of OCD. In view of the functional similarities between the orbital cortex, the basolateral nucleus of the amygdala and the medial prefrontal cortex, the present study compared the effects of lesions to these three regions. The present study replicated the finding that lesions to the rat orbital cortex enhance compulsive lever pressing. In contrast, lesions to the dorsal medial prefrontal cortex and to the basolateral amygdala did not affect compulsive lever pressing. A comparison of these findings to current knowledge regarding similarities and differences in the functioning of the three regions sheds light on the mechanism by which signal attenuation induces compulsive lever pressing and on the role played by the orbital cortex in compulsive behaviour.
引用
收藏
页码:2252 / 2262
页数:11
相关论文
共 94 条
[61]   A CYBERNETIC MODEL OF OBSESSIVE-COMPULSIVE PSYCHOPATHOLOGY [J].
PITMAN, RK .
COMPREHENSIVE PSYCHIATRY, 1987, 28 (04) :334-343
[62]   The role of ventromedial prefrontal cortex in the recovery of extinguished fear [J].
Quirk, GJ ;
Russo, GK ;
Barron, JL ;
Lebron, K .
JOURNAL OF NEUROSCIENCE, 2000, 20 (16) :6225-6231
[63]  
Ragozzino ME, 1999, J NEUROSCI, V19, P4585
[64]   Involvement of rodent prefrontal cortex subregions in strategy switching [J].
Ragozzino, ME ;
Wilcox, C ;
Raso, M ;
Kesner, RP .
BEHAVIORAL NEUROSCIENCE, 1999, 113 (01) :32-41
[65]  
RASMUSSEN SA, 1992, PSYCHIAT CLIN N AM, V15, P743
[66]  
RAUCH SL, 1994, ARCH GEN PSYCHIAT, V51, P62
[67]   OBSESSIONAL PERSONALITY-DISORDER AND REMEMBERING [J].
REED, GF .
BRITISH JOURNAL OF PSYCHIATRY, 1977, 130 (FEB) :177-183
[68]  
Rolls E.T., 1999, The brain and emotion
[69]   The orbitofrontal cortex [J].
Rolls, ET .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1996, 351 (1346) :1433-1443
[70]   The orbitofrontal cortex and reward [J].
Rolls, ET .
CEREBRAL CORTEX, 2000, 10 (03) :284-294