Deliberations of the Strategic Advisory Group of Experts on Immunization on the use of CYD-TDV dengue vaccine

被引：116

作者：

Wilder-Smith, Annelies ^{[1
]}

Hombach, Joachim ^{[1
]}

Ferguson, Neil ^{[2
]}

Selgelid, Michael ^{[3
]}

Brien, Kate O. ^{[4
]}

Vannice, Kirsten ^{[1
]}

Barrett, Alan ^{[5
]}

Ferdinand, Elizabeth ^{[6
]}

Flasche, Stefan ^{[7
]}

Guzman, Maria ^{[8
]}

Novaes, Hillegonde Maria ^{[9
]}

Ng, Lee-Ching ^{[10
]}

Smith, Peter G. ^{[7
]}

Tharmaphornpilas, Piyanit ^{[11
]}

Yoon, In-Kyu ^{[12
]}

Cravioto, Alejandro ^{[13
]}

Farrar, Jeremy ^{[14
]}

Nolan, Terry M. ^{[15
]}

机构：

[1] WHO, Initiat Vaccine Res, CH-1211 Geneva, Switzerland

[2] Imperial Coll, Dept Infect Dis Epidemiol, London, England

[3] Monash Univ, WHO, Collaborating Ctr Bioeth, Monash Bioeth Ctr, Melbourne, Vic, Australia

[4] Johns Hopkins Bloomberg Sch Publ Hlth, Int Vaccine Access Ctr, Baltimore, MD USA

[5] Univ Texas Med Branch, Galveston, TX 77555 USA

[6] Univ West Indies, Fac Med Sci, Bridgetown, Barbados

[7] London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, London, England

[8] Pedro Kouri Trop Med Inst, Havannah, Cuba

[9] Univ Sao Paulo, Fac Med Sci, Sao Paulo, Brazil

[10] Natl Environm Agcy, Environm Hlth Inst, Singapore, Singapore

[11] Minist Publ Hlth, Bangkok, Thailand

[12] Int Vaccine Inst, Seoul, South Korea

[13] Univ Nacl Autonoma Mexico, Fac Med, Mexico City, DF, Mexico

[14] Wellcome Trust Res Labs, London, England

[15] Univ Melbourne, Sch Populat & Global Hlth, Melbourne, Vic, Australia

来源：

LANCET INFECTIOUS DISEASES | 2019年 / 19卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

RECOMMENDATIONS; EFFICACY; CHILDREN;

D O I：

10.1016/S1473-3099(18)30494-8

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The Strategic Advisory Group of Experts (SAGE) on Immunization advises WHO on global policies for vaccines. In April, 2016, SAGE issued recommendations on the use of the first licenced dengue vaccine, CYD-TDV. In November, 2017, a retrospective analysis of clinical trial data, stratifying participants according to their dengue serostatus before the first vaccine dose, showed that although in high seroprevalence settings the vaccine provides overall population benefit, there was an excess risk of severe dengue in seronegative vaccinees. SAGE's working group on dengue vaccines met to discuss the new data and mainly considered two vaccination strategies: vaccination of populations with dengue seroprevalence rates above 80% or screening of individuals before vaccination, and vaccinating only seropositive individuals. We report on the deliberations that informed the recommendation of the pre-vaccination screening strategy, in April, 2018. Important research and implementation questions remain for CYD-TDV, including the development of a highly sensitive and specific rapid diagnostic test to determine serostatus, simplified immunisation schedules, and assessment of the need for booster doses.

引用

页码：E31 / E38

页数：8

共 45 条

[31] A Moderate Pluralist Approach to Public Health Policy and Ethics [J].

Selgelid, Michael J. .

PUBLIC HEALTH ETHICS, 2009, 2 (02) :195-205

[32]

Sridhar S, 2018, NEW ENGL J MED, V379, P327, DOI [10.1056/NEJMoa1800820, 10.1056/nejmoa1800820]

[33] Projected costs associated with school-based screening to inform deployment of Dengvaxia: Vietnam as a case study [J].

Turner, Hugo C. ;

Wills, Bridget A. ;

Rahman, Motiur ;

Hoang Quoc Cuong ;

Thwaites, Guy E. ;

Boni, Maciej F. ;

Clapham, Hannah E. .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2018, 112 (08) :369-377

[34] Clinical development and regulatory points for consideration for second-generation live attenuated dengue vaccines [J].

Vannice, Kirsten S. ;

Wilder-Smith, Annelies ;

Barrett, Alan D. T. ;

Carrijo, Kalinka ;

Cavaleri, Marco ;

de Silva, Aravinda ;

Durbin, Anna P. ;

Endy, Tim ;

Harris, Eva ;

Innis, Bruce L. ;

Katzelnick, Leah C. ;

Smith, Peter G. ;

Sun, Wellington ;

Thomas, Stephen J. ;

Hombach, Joachim .

VACCINE, 2018, 36 (24) :3411-3417

[35] Efficacy of a Tetravalent Dengue Vaccine in Children in Latin America [J].

Villar, Luis ;

Dayan, Gustavo Horacio ;

Luis Arredondo-Garcia, Jose ;

Maribel Rivera, Doris ;

Cunha, Rivaldo ;

Deseda, Carmen ;

Reynales, Humberto ;

Costa, Maria Selma ;

Morales-Ramirez, Javier Osvaldo ;

Carrasquilla, Gabriel ;

Rey, Luis Carlos ;

Dietze, Reynaldo ;

Luz, Kleber ;

Rivas, Enrique ;

Miranda Montoya, Maria Consuelo ;

Cortes Supelano, Margarita ;

Zambrano, Betzana ;

Langevin, Edith ;

Boaz, Mark ;

Tornieporth, Nadia ;

Saville, Melanie ;

Noriega, Fernando .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (02) :113-123

[36] Seroprevalence of antibodies to dengue and chikungunya viruses in Thailand [J].

Vongpunsawad, Sompong ;

Intharasongkroh, Duangnapa ;

Thongmee, Thanunrat ;

Poovorawan, Yong .

PLOS ONE, 2017, 12 (06)

[37] Development of TV003/TV005, a single dose, highly immunogenic live attenuated dengue vaccine; what makes this vaccine different from the Sanofi-Pasteur CYD™ vaccine? [J].

Whitehead, Stephen S. .

EXPERT REVIEW OF VACCINES, 2016, 15 (04) :509-517

[38]

WHO, 2018, SAGE M REP APR 2018

[39]

WHO, 2011, GUID QUAL SAF EFF DE

[40]

WHO, 2017, REC SAGE WORK GROUP

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