Decisions, decisions:: β-catenin chooses between adhesion and transcription

被引：161

作者：

Harris, TJC

Peifer, M

机构：

[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

TRENDS IN CELL BIOLOGY | 2005年 / 15卷 / 05期

关键词：

D O I：

10.1016/j.tcb.2005.03.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

beta-catenin functions in both cell adhesion and transcription. Properly choosing between these functions is crucial for normal development, and the wrong choice can lead to cancer. Recent studies have revealed molecular switches that help dictate whether beta-catenin interacts with adhesive or transcriptional complexes. Cara Gottardi and Barry Gumbiner identify Wnt-induced beta-catenin conformational changes that favor assembly into transcription complexes, whereas alpha-catenin-associated beta-catenin appears to favor adhesion. Furthermore, Felix Brembeck and colleagues reveal that phosphorylation dissociates beta-catenin from adhesion complexes while enhancing BCL9-2 binding to promote transcription.

引用

收藏

页码：234 / 237

页数：4

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