Nanosilver: A nanoproduct in medical application

被引:1415
作者
Chen, X. [1 ]
Schluesener, H. J. [1 ]
机构
[1] Univ Tubingen, Inst Brain Res, D-72076 Tubingen, Germany
关键词
silver; nanoparticles; rout of entry; toxicity; mechanism;
D O I
10.1016/j.toxlet.2007.10.004
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Nanotechnology is a most promising field for generating new applications in medicine. However, only few nanoproducts are currently in use for medical purposes. A most prominent nanoproduct is nanosilver. Nanosilver particles are generally smaller than 100 nm and contain 20-15,000 silver atoms. At nanoscale, silver exhibits remarkably unusual physical, chemical and biological properties. Due to its strong antibacterial activity, nanosilver coatings are used on various textiles but as well as coatings on certain implants. Further, nanosilver is used for treatment of wounds and bums or as a contraceptive and marketed as a water disinfectant and room spray. Thus, use of nanosilver is becoming more and more widespread in medicine and related applications and due to increasing exposure toxicological and environmental issues need to be raised. In sharp contrast to the attention paid to new applications of nanosilver, few studies provide only scant insights into the interaction of nanosilver particle with the human body after entering via different portals. Biodistribution, organ accumulation, degradation, possible adverse effects and toxicity are only slowly recognized and this review is focusing on major questions associated with the increased medical use of nanosilver and related nanomaterials. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:1 / 12
页数:12
相关论文
共 147 条
[91]   Nanotoxicology:: An emerging discipline evolving from studies of ultrafine particles [J].
Oberdörster, G ;
Oberdörster, E ;
Oberdörster, J .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2005, 113 (07) :823-839
[92]   Translocation of inhaled ultrafine particles to the brain [J].
Oberdörster, G ;
Sharp, Z ;
Atudorei, V ;
Elder, A ;
Gelein, R ;
Kreyling, W ;
Cox, C .
INHALATION TOXICOLOGY, 2004, 16 (6-7) :437-445
[93]  
Oberdorster G., 1988, J AEROSOL MED, V1, P289, DOI DOI 10.1089/JAM.1988.1.289
[94]   Argyria and convulsive seizures caused by ingestion of silver in a patient with schizophrenia [J].
Ohbo, Y ;
Fukuzako, H ;
Takeuchi, K ;
Takigawa, M .
PSYCHIATRY AND CLINICAL NEUROSCIENCES, 1996, 50 (02) :89-90
[95]   Mineral particles of varying composition induce differential chemokine release from epithelial lung cells:: Importance of physico-chemical characteristics [J].
Ovrevik, J ;
Myran, T ;
Refsnes, M ;
Låg, M ;
Becher, R ;
Hetland, RB ;
Schwarze, PE .
ANNALS OF OCCUPATIONAL HYGIENE, 2005, 49 (03) :219-231
[96]   Effect of different wound dressings on cell viability and proliferation [J].
Paddle-Ledinek, Joanne E. ;
Nasa, Zeyad ;
Cleland, Heather J. .
PLASTIC AND RECONSTRUCTIVE SURGERY, 2006, 117 (07) :110S-118S
[97]   Occupational exposure to crystalline silica and autoimmune disease [J].
Parks, CG ;
Conrad, K ;
Cooper, GS .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1999, 107 :793-802
[98]   Translocation and potential neurological effects of fine and ultrafine particles a critical update [J].
Peters, Annette ;
Veronesi, Bellina ;
Calderon-Garciduenas, Lilian ;
Gehr, Peter ;
Chen, Lung Chi ;
Geiser, Marianne ;
Reed, William ;
Rothen-Rutishauser, Barbara ;
Schuerch, Samuel ;
Schulz, Holger .
PARTICLE AND FIBRE TOXICOLOGY, 2006, 3 (01)
[99]   Effects of nano-scaled particles on endothelial cell function in vitro:: Studies on viability, proliferation and inflammation [J].
Peters, K ;
Unger, RE ;
Kirkpatrick, CJ ;
Gatti, AM ;
Monari, E .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2004, 15 (04) :321-325
[100]   In vitro cytotoxity of silver: implication for clinical wound care [J].
Poon, VKM ;
Burd, A .
BURNS, 2004, 30 (02) :140-147