Synthesis of novel fluorinated coumarins: Excellent UV-light excitable fluorescent dyes

被引：177

作者：

Sun, WC ^{[1
]}

Gee, KR ^{[1
]}

Haugland, RP ^{[1
]}

机构：

[1] Mol Probes Inc, Eugene, OR 97402 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(98)00578-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new fluorinated fluorescent dyes, 6,8-difluoro-7-hydroxy-4-methylcoumarin (Marina Blue(TM)) and 3-carboxy-6,8-difluoro-7-hydroxycoumarin (Pacific Blue(TM)), exhibit excellent photophysical properties among a series of novel fluorinated 7-hydroxycoumarins. Most of these fluorinated coumarins have quantum yields (0.63 to 0.89) equal to or higher than that of the parent compound (0.63), which, in combination with their lower pK(a)s and higher photostability, make them superior fluorescent dyes fbr use as reporter molecules in biological systems. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3107 / 3110

页数：4

共 18 条

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