Is frontal lobe involved in the generation of auditory evoked P50?

被引：102

作者：

Weisser, R

Weisbrod, M

Roehrig, M

Rupp, A

Schroeder, J

Scherg, M

机构：

[1] Univ Heidelberg, Dept Psychiat, D-69115 Heidelberg, Germany

[2] Univ Heidelberg, Dept Neurol, Sect Biomagnetism, D-69115 Heidelberg, Germany

来源：

NEUROREPORT | 2001年 / 12卷 / 15期

关键词：

AEF; AEP; auditory cortex; EEG; frontal lobe; MEG; P30m; P50; sensory gating; spatio-temporal source analysis;

D O I：

10.1097/00001756-200110290-00031

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study examined the functional substrate of P50 suppression. Auditory evoked potentials (AEPs) and magnetic fields (AEFs) were recorded from healthy subjects simultaneously and analyzed using spatio-temporal source analysis. The resulting equivalent dipole model for the AEP consisted of one source in the auditory cortex (AC) of each hemisphere and an radially oriented medial frontal source, both with maximum AEP activity around 50 ms. The frontal source was functionally separated from the AC sources since it peaked significantly later and showed significantly larger P50 amplitude suppression. P30m showed neither suppression nor substantial frontal activity. In sum, this study relates P50 suppression to reduction of AC source activity and is the first to yield direct evidence for frontal involvement in P50 suppression. NeuroReport 12:3303-3307 (C) 2001 Lippincott Williams. & Wilkins.

引用

页码：3303 / 3307

页数：5

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