Immunological complications of obesity

被引：395

作者：

Kanneganti, Thirumala-Devi ^{[1
]}

Dixit, Vishwa Deep ^{[2
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

[2] Louisiana State Univ Syst, Immunobiol Lab, Pennington Biomed Res Ctr, Baton Rouge, LA USA

来源：

NATURE IMMUNOLOGY | 2012年 / 13卷 / 08期

关键词：

INDUCED WEIGHT-LOSS; ADIPOSE-TISSUE; INSULIN-RESISTANCE; T-CELLS; NLRP3; INFLAMMASOME; REPERTOIRE DIVERSITY; IMMUNE-RESPONSE; M2; MACROPHAGES; B-CELLS; ACTIVATION;

D O I：

10.1038/ni.2343

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Current approaches for the treatment of obesity, including diet and lifestyle changes, have not been successful in curtailing the obesity epidemic. The higher incidence of inflammation-associated chronic disease and greater susceptibility to infection in obese people represents a growing health threat. Improved understanding of the immunological processes that regulate obesity may yield new treatments for obesity-associated disorders.

引用

页码：707 / 712

页数：6

共 67 条

[1]

IKK-β links inflammation to obesity-induced insulin resistance [J].

Arkan, MC ;

Hevener, AL ;

Greten, FR ;

Maeda, S ;

Li, ZW ;

Long, JM ;

Wynshaw-Boris, A ;

Poli, G ;

Olefsky, J ;

Karin, M .

NATURE MEDICINE, 2005, 11 (02) :191-198

[2]

PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties [J].

Bouhlel, M. Amine ;

Derudas, Bruno ;

Rigamonti, Elena ;

Dievart, Rebecca ;

Brozek, John ;

Haulon, Stephan ;

Zawadzki, Christophe ;

Jude, Brigitte ;

Torpier, Gerard ;

Marx, Nikolaus ;

Staels, Bart ;

Chinetti-Gbaguidi, Giulia .

CELL METABOLISM, 2007, 6 (02) :137-143

[3]

Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery induced weight loss [J].

Cancello, R ;

Henegar, C ;

Viguerie, N ;

Taleb, S ;

Poitou, C ;

Rouault, C ;

Coupaye, M ;

Pelloux, V ;

Hugol, D ;

Bouillot, JL ;

Bouloumié, A ;

Barbatelli, G ;

Cinti, S ;

Svensson, PA ;

Barsh, GS ;

Zucker, JD ;

Basdevant, A ;

Langin, D ;

Clément, K .

DIABETES, 2005, 54 (08) :2277-2286

[4]

Macrophage-mediated inflammation in metabolic disease [J].

Chawla, Ajay ;

Nguyen, Khoa D. ;

Goh, Y. P. Sharon .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (11) :738-749

[5]

CLARK A, 1988, DIABETES RES CLIN EX, V9, P151

[6]

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals [J].

Duewell, Peter ;

Kono, Hajime ;

Rayner, Katey J. ;

Sirois, Cherilyn M. ;

Vladimer, Gregory ;

Bauernfeind, Franz G. ;

Abela, George S. ;

Franchi, Luigi ;

Nunez, Gabriel ;

Schnurr, Max ;

Espevik, Terje ;

Lien, Egil ;

Fitzgerald, Katherine A. ;

Rock, Kenneth L. ;

Moore, Kathryn J. ;

Wright, Samuel D. ;

Hornung, Veit ;

Latz, Eicke .

NATURE, 2010, 464 (7293) :1357-U7

[7]

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis [J].

Elinav, Eran ;

Strowig, Till ;

Kau, Andrew L. ;

Henao-Mejia, Jorge ;

Thaiss, Christoph A. ;

Booth, Carmen J. ;

Peaper, David R. ;

Bertin, John ;

Eisenbarth, Stephanie C. ;

Gordon, Jeffrey I. ;

Flavell, Richard A. .

CELL, 2011, 145 (05) :745-757

[8]

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency [J].

Farooqi, IS ;

Matarese, G ;

Lord, GM ;

Keogh, JM ;

Lawrence, E ;

Agwu, C ;

Sanna, V ;

Jebb, SA ;

Perna, F ;

Fontana, S ;

Lechler, RI ;

DePaoli, AM ;

O'Rahilly, S .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (08) :1093-1103

[9]

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters [J].

Feuerer, Markus ;

Herrero, Laura ;

Cipolletta, Daniela ;

Naaz, Afia ;

Wong, Jamie ;

Nayer, Ali ;

Lee, Jongsoon ;

Goldfine, Allison B. ;

Benoist, Christophe ;

Shoelson, Steven ;

Mathis, Diane .

NATURE MEDICINE, 2009, 15 (08) :930-U137

[10]

Targeted Deletion of Adipocytes by Apoptosis Leads to Adipose Tissue Recruitment of Alternatively Activated M2 Macrophages [J].

Fischer-Posovszky, Pamela ;

Wang, Qiong A. ;

Asterholm, Ingrid Wernstedt ;

Rutkowski, Joseph M. ;

Scherer, Philipp E. .

ENDOCRINOLOGY, 2011, 152 (08) :3074-3081

← 1 2 3 4 5 6 7 →