Macrophage-mediated inflammation in metabolic disease

被引：1054

作者：

Chawla, Ajay ^{[1
,2
,3
]}

Nguyen, Khoa D. ^{[2
,3
,4
]}

Goh, Y. P. Sharon ^{[1
,4
]}

机构：

[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94158 USA

[4] Stanford Univ, Program Immunol, Stanford, CA 94305 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 11期

基金：

美国国家卫生研究院;

关键词：

OBESITY-INDUCED INFLAMMATION; DIET-INDUCED OBESITY; BODY-MASS INDEX; INSULIN-RESISTANCE; ADIPOSE-TISSUE; PPAR-GAMMA; T-CELLS; CHEMOATTRACTANT PROTEIN-1; ALTERNATIVE ACTIVATION; NLRP3; INFLAMMASOME;

D O I：

10.1038/nri3071

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Metabolism and immunity are two fundamental systems of metazoans. The presence of immune cells, such as macrophages, in metabolic tissues suggests dynamic, ongoing crosstalk between these two regulatory systems. Here, we discuss how changes in the recruitment and activation of macrophages contribute to metabolic homeostasis. In particular, we focus our discussion on the pathogenic and protective functions of classically and alternatively activated macrophages, respectively, in experimental models of obesity and metabolic disease.

引用

页码：738 / 749

页数：12

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