Sterile inflammation: sensing and reacting to damage

被引：2295

作者：

Chen, Grace Y. ^{[1
]}

Nunez, Gabriel ^{[2
]}

机构：

[1] Univ Michigan, Dept Internal Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Pathol, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 12期

基金：

美国国家卫生研究院;

关键词：

END-PRODUCTS RAGE; HEAT-SHOCK PROTEINS; APOPTOTIC CELL-DEATH; SMOOTH-MUSCLE-CELLS; TOLL-LIKE RECEPTORS; NALP3; INFLAMMASOME; NLRP3; OXIDATIVE STRESS; INNATE IMMUNITY; MICE DEFICIENT;

D O I：

10.1038/nri2873

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Over the past several decades, much has been revealed about the nature of the host innate immune response to microorganisms, with the identification of pattern recognition receptors (PRRs) and pathogen-associated molecular patterns, which are the conserved microbial motifs sensed by these receptors. It is now apparent that these same PRRs can also be activated by non-microbial signals, many of which are considered as damage-associated molecular patterns. The sterile inflammation that ensues either resolves the initial insult or leads to disease. Here, we review the triggers and receptor pathways that result in sterile inflammation and its impact on human health.

引用

页码：826 / 837

页数：12

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